De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression

Takuro Igawa, Yasuharu Sato, Katsuyoshi Takata, Noriko Iwaki, Takehiro Tanaka, Naoko Asano, Yoshinobu Maeda, Yorihisa Orita, Naoya Nakamura, Shigeo Nakamura, Tadashi Yoshino

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

D cyclins positively regulate the cell cycle and mediate the pathogenesis of some lymphomas. Cyclin D1 overexpression is the hallmark of mantle cell lymphoma, whereas cyclins D2 and D3 are reportedly not as specific to certain lymphomas as cyclin D1. In this study, cyclin D2 was found to be overexpressed in 98% of de novo CD5-positive diffuse large B-cell lymphomas (DLBCLs) (50/51) and in 28% of CD5-negative DLBCLs (14/51). A statistically significant difference was observed between these two groups (p

Original languageEnglish
Article number81
JournalDiagnostic Pathology
Volume8
Issue number1
DOIs
Publication statusPublished - May 15 2013

Fingerprint

Cyclin D2
Lymphoma, Large B-Cell, Diffuse
Cyclin D1
Lymphoma
Cyclin D3
Cyclin D
Mantle-Cell Lymphoma
Cell Cycle

Keywords

  • CD5
  • Cyclin D2
  • Diffuse large B-cell lymphoma

ASJC Scopus subject areas

  • Histology
  • Pathology and Forensic Medicine

Cite this

De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression. / Igawa, Takuro; Sato, Yasuharu; Takata, Katsuyoshi; Iwaki, Noriko; Tanaka, Takehiro; Asano, Naoko; Maeda, Yoshinobu; Orita, Yorihisa; Nakamura, Naoya; Nakamura, Shigeo; Yoshino, Tadashi.

In: Diagnostic Pathology, Vol. 8, No. 1, 81, 15.05.2013.

Research output: Contribution to journalArticle

Igawa, Takuro ; Sato, Yasuharu ; Takata, Katsuyoshi ; Iwaki, Noriko ; Tanaka, Takehiro ; Asano, Naoko ; Maeda, Yoshinobu ; Orita, Yorihisa ; Nakamura, Naoya ; Nakamura, Shigeo ; Yoshino, Tadashi. / De novo CD5-positive diffuse large B-cell lymphomas show high specificity for cyclin D2 expression. In: Diagnostic Pathology. 2013 ; Vol. 8, No. 1.
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AU - Takata, Katsuyoshi

AU - Iwaki, Noriko

AU - Tanaka, Takehiro

AU - Asano, Naoko

AU - Maeda, Yoshinobu

AU - Orita, Yorihisa

AU - Nakamura, Naoya

AU - Nakamura, Shigeo

AU - Yoshino, Tadashi

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