Day/night variation of 5-hydroxyindole acetic acid concentration in rat cerebrospinal fluid after acute and long-term administration of a selective serotonin reuptake inhibitor, fluvoxamine

T. Egashira, F. Takayama, Y. Yamanaka, K. Takada, H. Takeda, T. Matsumiya

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

When 30 mg/kg, p.o. of fluvoxamine, a selective serotonin reuptake inhibitor, was administered, significant increases of 3-methoxy-4-hydroxyphenylglycol (MHPG) and 5-hydroxy indole-3-acetic acid (5-HIAA) contents in rat cerebrospinal fluid (CSF) were observed from two days after administration of fluvoxamine in both the light and dark periods and in the dark period of the light/dark cycle, respectively. In long-term treatment with 15 mg/kg, p.o. of fluvoxamine, the level of MHPG in CSF exhibited no difference, whereas the levels of 5-HIAA showed a significant increase during the light periods. These results suggest that fluvoxamine enhances the 5-HT system, but only with long-term treatment.

Original languageEnglish
Pages (from-to)344-347
Number of pages4
JournalJapanese Journal of Pharmacology
Volume83
Issue number4
DOIs
Publication statusPublished - Sep 23 2000
Externally publishedYes

Keywords

  • Cerebrospinal fluid
  • Monoamine metabolite
  • Selective serotonin reuptake inhibitor

ASJC Scopus subject areas

  • Pharmacology

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