Abstract
The danger model is based on the premise that the innate immune system has evolved to recognize danger by activating antigen presenting cells (APCs) in inflammatory tissues, resulting in the induction of adaptive immunity in some cases. Recently, Toll-like receptor-signaling has been highlighted as a signal for growth, activation and maturation of APCs, and is considered to consist of the large part of danger signals. Old BRMs like BCG, OK-432 and PSK that have been used clinically for a long time should be reassessed as to whether or not they are ligands for Toll-like receptors, and reused in cancer immunotherapy, The relationship of Toll-like receptor-signaling and differentiation, activation and maturation of human dendritic cells has also been commented on in detail for future dendritic cell therapy against cancer.
| Original language | English |
|---|---|
| Pages (from-to) | 204-210 |
| Number of pages | 7 |
| Journal | Biotherapy |
| Volume | 16 |
| Issue number | 3 |
| Publication status | Published - 2002 |
| Externally published | Yes |
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Keywords
- Cancer immunotherapy
- Danger signal
- Toll-like receptor
ASJC Scopus subject areas
- Cancer Research
- Immunology and Allergy
Cite this
Danger signal, Toll-like receptor, and cancer immunotherapy. / Orita, Kunzo; Gochi, Akira; Nakamura, Shuji; Motoda, Ryuichi.
In: Biotherapy, Vol. 16, No. 3, 2002, p. 204-210.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Danger signal, Toll-like receptor, and cancer immunotherapy
AU - Orita, Kunzo
AU - Gochi, Akira
AU - Nakamura, Shuji
AU - Motoda, Ryuichi
PY - 2002
Y1 - 2002
N2 - The danger model is based on the premise that the innate immune system has evolved to recognize danger by activating antigen presenting cells (APCs) in inflammatory tissues, resulting in the induction of adaptive immunity in some cases. Recently, Toll-like receptor-signaling has been highlighted as a signal for growth, activation and maturation of APCs, and is considered to consist of the large part of danger signals. Old BRMs like BCG, OK-432 and PSK that have been used clinically for a long time should be reassessed as to whether or not they are ligands for Toll-like receptors, and reused in cancer immunotherapy, The relationship of Toll-like receptor-signaling and differentiation, activation and maturation of human dendritic cells has also been commented on in detail for future dendritic cell therapy against cancer.
AB - The danger model is based on the premise that the innate immune system has evolved to recognize danger by activating antigen presenting cells (APCs) in inflammatory tissues, resulting in the induction of adaptive immunity in some cases. Recently, Toll-like receptor-signaling has been highlighted as a signal for growth, activation and maturation of APCs, and is considered to consist of the large part of danger signals. Old BRMs like BCG, OK-432 and PSK that have been used clinically for a long time should be reassessed as to whether or not they are ligands for Toll-like receptors, and reused in cancer immunotherapy, The relationship of Toll-like receptor-signaling and differentiation, activation and maturation of human dendritic cells has also been commented on in detail for future dendritic cell therapy against cancer.
KW - Cancer immunotherapy
KW - Danger signal
KW - Toll-like receptor
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UR - http://www.scopus.com/inward/citedby.url?scp=0036291891&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0036291891
VL - 16
SP - 204
EP - 210
JO - Biotherapy
JF - Biotherapy
SN - 0914-2223
IS - 3
ER -