D2 dopamine receptor alleles influence prognosis of methamphetamine psychosis

H. Ujike, K. Nakata, Manabu Takaki, T. Inada, M. Harano, M. Yamada, N. Ozaki

Research output: Contribution to journalArticle

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Abstract

The present study was done by JGIDA (Japanese Genetic Initiative for Drug Abuse), consisting of above authors and A. Sakai, H. T. Komiyama, Mitsushio, Y. Sekine, T. Maeda, S. Iwashita, I. Sora and M. Iyo. Previous studies indicated that polymorphisms of D2 dopamine receptor showed a possible association with alcoholism, pathological gambling, smoking and several personality traits. We examined association study between the patients with methamphetamine psychosis and TaqI A alleles of DRD2. Subjects were 115 methamphetamine users and age- and sex-matched 112 controls. All were Japanese. There was no significant difference in genotypic and allelic distribution of TaqI A between all methamphetamine users and controls. However, the patients with prolonged methamphetamine psychosis (lasting more than 1 month after therapy) showed a significant excess A2 positive genotype (p + ADO-0.0098) than those with transient psychosis (psychotic symptoms disappeared within 1 month after therapy). The patients with flashback also showed a significant excess A2 positive genotype than those without flashback (p + ADO-0.0049). A2 allele of TaqI polymorphism of DRD2 may confer prolongation of psychotic phase and liability to flashback.

Original languageEnglish
Pages (from-to)617
Number of pages1
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume105
Issue number7
Publication statusPublished - Oct 8 2001

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Dopamine D2 Receptors
Methamphetamine
Psychotic Disorders
Alleles
varespladib methyl
Genotype
Gambling
Alcoholism
Substance-Related Disorders
Personality
Smoking
Therapeutics
beta-apocarotenoid-14',13'-dioxygenase

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

D2 dopamine receptor alleles influence prognosis of methamphetamine psychosis. / Ujike, H.; Nakata, K.; Takaki, Manabu; Inada, T.; Harano, M.; Yamada, M.; Ozaki, N.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 105, No. 7, 08.10.2001, p. 617.

Research output: Contribution to journalArticle

Ujike, H. ; Nakata, K. ; Takaki, Manabu ; Inada, T. ; Harano, M. ; Yamada, M. ; Ozaki, N. / D2 dopamine receptor alleles influence prognosis of methamphetamine psychosis. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2001 ; Vol. 105, No. 7. pp. 617.
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