D1/D2 receptor synergism on CREB DNA-binding activities in the caudate- putamen of rat

Kenichi Kashihara, Takeshi Ishihara, Kazufumi Akiyama, Koji Abe

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Cyclic AMP-responsive element-binding protein (CREB) is a transcription factor that is activated by cyclic AMP-dependent protein kinase and regulates the induction of fos. In order to elucidate the cellular pathway of D1/D2 dopamine receptor synergism, the effect of D1 and D2 agonists on CREB DNA- binding activities was studied in the caudate-putamen of rats with an ipsilateral 6-hydroxydopamine-lesion of the medial forebrain bundle. Combined administration of D1 (SKF38393) and D2 (bromocriptine or quinpirole) agonists resulted in enhanced CREB-binding activities at a dose that did not enhance it when given separately. These results suggest that D1/D2 dopamine receptors play synergistic role in inducing CREB DNA-binding activities in the dopamine-depleted caudate-putamen of rats.

Original languageEnglish
Pages (from-to)781-784
Number of pages4
JournalNeurological Research
Volume21
Issue number8
Publication statusPublished - 1999

Fingerprint

Putamen
Protein Binding
Cyclic AMP
Carrier Proteins
Dopamine D1 Receptors
Dopamine D2 Receptors
Medial Forebrain Bundle
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Quinpirole
Bromocriptine
Oxidopamine
Cyclic AMP-Dependent Protein Kinases
Dopamine
Transcription Factors

Keywords

  • CREB
  • Dopamine receptor
  • Striatum
  • Synergism

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

D1/D2 receptor synergism on CREB DNA-binding activities in the caudate- putamen of rat. / Kashihara, Kenichi; Ishihara, Takeshi; Akiyama, Kazufumi; Abe, Koji.

In: Neurological Research, Vol. 21, No. 8, 1999, p. 781-784.

Research output: Contribution to journalArticle

Kashihara, K, Ishihara, T, Akiyama, K & Abe, K 1999, 'D1/D2 receptor synergism on CREB DNA-binding activities in the caudate- putamen of rat', Neurological Research, vol. 21, no. 8, pp. 781-784.
Kashihara, Kenichi ; Ishihara, Takeshi ; Akiyama, Kazufumi ; Abe, Koji. / D1/D2 receptor synergism on CREB DNA-binding activities in the caudate- putamen of rat. In: Neurological Research. 1999 ; Vol. 21, No. 8. pp. 781-784.
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