d-Serine controls epidermal vesicle release via NMDA receptor, allowing tissue migration during the metamorphosis of the chordate Ciona

Gabriel Krasovec, Akiko Hozumi, Tomoyuki Yoshida, Takayuki Obita, Mayuko Hamada, Akira Shiraishi, Honoo Satake, Takeo Horie, Hisashi Mori, Yasunori Sasakura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

d-Serine, a free amino acid synthesized by serine racemase, is a coagonist of N-methyl-d-aspartate–type glutamate receptor (NMDAR). d-Serine in the mammalian central nervous system modulates glutamatergic transmission. Functions of d-serine in mammalian peripheral tissues such as skin have also been described. However, d-serine’s functions in nonmammals are unclear. Here, we characterized d-serine–dependent vesicle release from the epidermis during metamorphosis of the tunicate Ciona. d-Serine leads to the formation of a pocket that facilitates the arrival of migrating tissue during tail regression. NMDAR is the receptor of d-serine in the formation of the epidermal pocket. The epidermal pocket is formed by the release of epidermal vesicles’ content mediated by d-serine/NMDAR. This mechanism is similar to observations of keratinocyte vesicle exocytosis in mammalian skin. Our findings provide a better understanding of the maintenance of epidermal homeostasis in animals and contribute to further evolutionary perspectives of d-amino acid function among metazoans.

Original languageEnglish
Article numbereabn3264
JournalScience Advances
Volume8
Issue number10
DOIs
Publication statusPublished - Mar 2022

ASJC Scopus subject areas

  • General

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