D-dimer level as a risk factor for postoperative venous thromboembolism in Japanese women with gynecologic cancer

J. Kodama, N. Seki, S. Masahiro, T. Kusumoto, Keiichiro Nakamura, A. Hongo, Y. Hiramatsu

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Background: The purpose of the present study was to evaluate whether early postoperative D-dimer levels and certain pre-, intra-, and postoperative parameters can be used to predict venous thromboembolism (VTE) in gynecologic cancer patients. Materials and methods: We prospectively evaluated 267 gynecologic cancer patients who underwent surgery at our institution. The plasma D-dimer level was measured serially before the operation and on certain postoperative days. After the operation, primary screening for VTE was undertaken by meticulous examination for clinical signs and elevation of the plasma D-dimer level. Seventy-five patients underwent multidetector row computed tomography and were subjected to further investigations. Results: VTE was detected in 21 of the 75 patients. There were significant differences in the D-dimer value between VTE-positive and VTE-negative patients on postoperative days 3, 5, and 7. The optimal cut-off value for the postoperative D-dimer level was determined as 5 μg/ml on day 3. Logistic regression multivariate analysis revealed that high D-dimer values on postoperative day 3, the use of recombinant human erythropoietin (rHuEPO), and non-O blood group were independent risk factors for postoperative VTE. Conclusion: High plasma D-dimer level on postoperative day 3, the use of rHuEPO, and non-O blood group were independent risk factors for postoperative VTE.

Original languageEnglish
Pages (from-to)1651-1656
Number of pages6
JournalAnnals of Oncology
Volume21
Issue number8
DOIs
Publication statusPublished - Feb 3 2010

Fingerprint

Venous Thromboembolism
Neoplasms
Blood Group Antigens
Erythropoietin
Multidetector Computed Tomography
fibrin fragment D
Multivariate Analysis
Logistic Models
Regression Analysis

Keywords

  • D-dimer
  • Erythropoietin
  • Gynecologic cancer
  • Non-O blood group
  • Venous thromboembolism

ASJC Scopus subject areas

  • Oncology
  • Hematology

Cite this

D-dimer level as a risk factor for postoperative venous thromboembolism in Japanese women with gynecologic cancer. / Kodama, J.; Seki, N.; Masahiro, S.; Kusumoto, T.; Nakamura, Keiichiro; Hongo, A.; Hiramatsu, Y.

In: Annals of Oncology, Vol. 21, No. 8, 03.02.2010, p. 1651-1656.

Research output: Contribution to journalArticle

Kodama, J. ; Seki, N. ; Masahiro, S. ; Kusumoto, T. ; Nakamura, Keiichiro ; Hongo, A. ; Hiramatsu, Y. / D-dimer level as a risk factor for postoperative venous thromboembolism in Japanese women with gynecologic cancer. In: Annals of Oncology. 2010 ; Vol. 21, No. 8. pp. 1651-1656.
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