Abstract
It has been known that pinealocytes contain the highest level of D- aspartate among various neuroendocrine cells in the rat. Here, we report that exogenous D-aspartate strongly inhibited norepinephrine-dependent melatonin synthesis in the rat pineal gland, the concentration required for 50% inhibition being 75 μM. This inhibition was due at least partly to decreased norepinephrine-dependent serotonin N-acetyltransferase activity. Upon incubation, D-aspartate was gradually released from pinealocytes and accumulated in the incubation medium as determined by high-performance liquid chromatography on a Pirkle-type chiral column. These results suggest that D- aspartate acts as a negative regulator for melatonin synthesis in the pineal gland.
| Original language | English |
|---|---|
| Pages (from-to) | 143-146 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 249 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Jun 19 1998 |
Keywords
- Cyclic AMP
- D-Aspartate
- L-Glutamate
- Melatonin
- Pinealocyte
- Regulation
- Serotonin N- acetyltransferase
ASJC Scopus subject areas
- Neuroscience(all)
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Cite this
Ishio, S., Yamada, H., Hayashi, M., Yatsushiro, S., Noumi, T., Yamaguchi, A., & Moriyama, Y. (1998). D-Aspartate modulates melatonin synthesis in rat pinealocytes. Neuroscience Letters, 249(2-3), 143-146. https://doi.org/10.1016/S0304-3940(98)00414-5