Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer

Tadashi Tsuchida, Hiromichi Yamane, Nobuaki Ochi, Takayuki Tabayashi, Akio Hiraki, Naoyuki Nogami, Nagio Takigawa, Katsuyuki Kiura, Mitsune Tanimoto

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Background/Aim: Although small-cell lung cancer (SCLC) is sensitive to anticancer agents, most patients with SCLC experience relapse and die within two years. Here, we examined the relationship between natural killer (NK) cells and adhesion molecules on SCLC cell lines. Materials and Methods: The expression levels of HLA class I, β2-microglobulin, Fas/Apo-1 receptor (FAS) and adhesion molecules on SCLC cell lines were examined by flow cytometry. The cytotoxicity of activated NK cells from SCLC patients was examined using 51Cr-release assay. Results: HLA class I antigen and β2-microglobulin expression levels in SCLC cell lines were lower than those in healthy volunteers. SCLC cell lines were susceptible to lysis by activated NK cells but this showed no correlation with expression levels of adhesion molecules. Conclusion: Target cell susceptibility to activated NK cells from five SCLC patients correlated with survival benefit; target cell susceptibility to activated NK cells may be a surrogate marker of outcome for patients with SCLC.

Original languageEnglish
Pages (from-to)887-892
Number of pages6
JournalAnticancer research
Volume32
Issue number3
Publication statusPublished - Mar 2012

Keywords

  • Adhesion molecules
  • HLA-class I
  • Natural killer cell
  • Small-cell lung cancer
  • Target cell susceptibility

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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    Tsuchida, T., Yamane, H., Ochi, N., Tabayashi, T., Hiraki, A., Nogami, N., Takigawa, N., Kiura, K., & Tanimoto, M. (2012). Cytotoxicity of activated natural killer cells and expression of adhesion molecules in small-cell lung cancer. Anticancer research, 32(3), 887-892.