Cytotoxic molecule-positive classical Hodgkin's lymphoma: A clinicopathological Comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type

Naoko Asano, Tomohiro Kinoshita, Jun Ichi Tamaru, Koichi Ohshima, Tadashi Yoshino, Nozomi Niitsu, Norifumi Tsukamoto, Kaoru Hirabayashi, Koji Izutsu, Masafumi Taniwaki, Yasuo Morishima, Shigeo Nakamura

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Abstract

Background Classical Hodgkin's lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin's lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin's lymphoma remain controversial. Design and Methods We investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin's lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic moleculenegative Hodgkin's lymphoma. Results The patients with cytotoxic molecule-positive Hodgkin's lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin's lymphoma had a prototypic immunophenotype of CD15 + CD30 + CD45RO - fascin +, with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin's lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin's lymphoma. Regarding prognosis, the survival of patients with cytotoxic moleculepositive Hodgkin's lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin's lymphoma (P=0.0003) but better than that of patients with cytotoxic moleculepositive peripheral T-cell lymphomas, not otherwise specified (P=0.002). Conclusions Cytotoxic molecule-positive Hodgkin's lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin's lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin's lymphoma is clearly required.

Original languageEnglish
Pages (from-to)1636-1643
Number of pages8
JournalHaematologica
Volume96
Issue number11
DOIs
Publication statusPublished - Nov 1 2011

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Peripheral T-Cell Lymphoma
Hodgkin Disease
Reed-Sternberg Cells
Hepatomegaly
Splenomegaly

Keywords

  • Classical hodgkin's lymphoma
  • Cytotoxic molecules
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Cytotoxic molecule-positive classical Hodgkin's lymphoma : A clinicopathological Comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type. / Asano, Naoko; Kinoshita, Tomohiro; Tamaru, Jun Ichi; Ohshima, Koichi; Yoshino, Tadashi; Niitsu, Nozomi; Tsukamoto, Norifumi; Hirabayashi, Kaoru; Izutsu, Koji; Taniwaki, Masafumi; Morishima, Yasuo; Nakamura, Shigeo.

In: Haematologica, Vol. 96, No. 11, 01.11.2011, p. 1636-1643.

Research output: Contribution to journalArticle

Asano, N, Kinoshita, T, Tamaru, JI, Ohshima, K, Yoshino, T, Niitsu, N, Tsukamoto, N, Hirabayashi, K, Izutsu, K, Taniwaki, M, Morishima, Y & Nakamura, S 2011, 'Cytotoxic molecule-positive classical Hodgkin's lymphoma: A clinicopathological Comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type', Haematologica, vol. 96, no. 11, pp. 1636-1643. https://doi.org/10.3324/haematol.2011.041079
Asano, Naoko ; Kinoshita, Tomohiro ; Tamaru, Jun Ichi ; Ohshima, Koichi ; Yoshino, Tadashi ; Niitsu, Nozomi ; Tsukamoto, Norifumi ; Hirabayashi, Kaoru ; Izutsu, Koji ; Taniwaki, Masafumi ; Morishima, Yasuo ; Nakamura, Shigeo. / Cytotoxic molecule-positive classical Hodgkin's lymphoma : A clinicopathological Comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type. In: Haematologica. 2011 ; Vol. 96, No. 11. pp. 1636-1643.
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AU - Kinoshita, Tomohiro

AU - Tamaru, Jun Ichi

AU - Ohshima, Koichi

AU - Yoshino, Tadashi

AU - Niitsu, Nozomi

AU - Tsukamoto, Norifumi

AU - Hirabayashi, Kaoru

AU - Izutsu, Koji

AU - Taniwaki, Masafumi

AU - Morishima, Yasuo

AU - Nakamura, Shigeo

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N2 - Background Classical Hodgkin's lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin's lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin's lymphoma remain controversial. Design and Methods We investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin's lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic moleculenegative Hodgkin's lymphoma. Results The patients with cytotoxic molecule-positive Hodgkin's lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin's lymphoma had a prototypic immunophenotype of CD15 + CD30 + CD45RO - fascin +, with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin's lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin's lymphoma. Regarding prognosis, the survival of patients with cytotoxic moleculepositive Hodgkin's lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin's lymphoma (P=0.0003) but better than that of patients with cytotoxic moleculepositive peripheral T-cell lymphomas, not otherwise specified (P=0.002). Conclusions Cytotoxic molecule-positive Hodgkin's lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin's lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin's lymphoma is clearly required.

AB - Background Classical Hodgkin's lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin's lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin's lymphoma remain controversial. Design and Methods We investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin's lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic moleculenegative Hodgkin's lymphoma. Results The patients with cytotoxic molecule-positive Hodgkin's lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin's lymphoma had a prototypic immunophenotype of CD15 + CD30 + CD45RO - fascin +, with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin's lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin's lymphoma. Regarding prognosis, the survival of patients with cytotoxic moleculepositive Hodgkin's lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin's lymphoma (P=0.0003) but better than that of patients with cytotoxic moleculepositive peripheral T-cell lymphomas, not otherwise specified (P=0.002). Conclusions Cytotoxic molecule-positive Hodgkin's lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin's lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin's lymphoma is clearly required.

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