Cytotoxic flavonoids from the flowers of Achillea millefolium

Chang Hong Huo; Yong Li; Man Li Zhang; Yu Fang Wang; Qing Zhang; Fang Qin; Qing Wen Shi; Hiromasa Kiyota

doi:10.1007/s10600-013-0438-y

Cytotoxic flavonoids from the flowers of Achillea millefolium

Chang Hong Huo, Yong Li, Man Li Zhang, Yu Fang Wang, Qing Zhang, Fang Qin, Qing Wen Shi, Hiromasa Kiyota

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

Original language	English
Pages (from-to)	958-962
Number of pages	5
Journal	Chemistry of Natural Compounds
Volume	48
Issue number	6
DOIs	https://doi.org/10.1007/s10600-013-0438-y
Publication status	Published - Jan 2013
Externally published	Yes

Keywords

Achillea millefolium
Compositae
antiproliferative activity
flavonoids

ASJC Scopus subject areas

Plant Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10600-013-0438-y

Cite this

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title = "Cytotoxic flavonoids from the flowers of Achillea millefolium",

abstract = "A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.",

keywords = "Achillea millefolium, Compositae, antiproliferative activity, flavonoids",

author = "Huo, {Chang Hong} and Yong Li and Zhang, {Man Li} and Wang, {Yu Fang} and Qing Zhang and Fang Qin and Shi, {Qing Wen} and Hiromasa Kiyota",

note = "Funding Information: Financial support by the National Natural Science Foundation of China (81072551), the Scientific Research Foundation for Returning Overseas Chinese Scholars of Hebei Province (2006-02), the Scientific Research Foundation of Hebei Province (08B032 and C2010000489), JSPS KAKENHI (22580112), and Syngenta Ltd. (2008-Hebei Medical University-Syngenta-02) is gratefully acknowledged. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2013",

month = jan,

doi = "10.1007/s10600-013-0438-y",

language = "English",

volume = "48",

pages = "958--962",

journal = "Chemistry of Natural Compounds",

issn = "0009-3130",

publisher = "Springer New York",

number = "6",

}

TY - JOUR

T1 - Cytotoxic flavonoids from the flowers of Achillea millefolium

AU - Huo, Chang Hong

AU - Li, Yong

AU - Zhang, Man Li

AU - Wang, Yu Fang

AU - Zhang, Qing

AU - Qin, Fang

AU - Shi, Qing Wen

AU - Kiyota, Hiromasa

N1 - Funding Information: Financial support by the National Natural Science Foundation of China (81072551), the Scientific Research Foundation for Returning Overseas Chinese Scholars of Hebei Province (2006-02), the Scientific Research Foundation of Hebei Province (08B032 and C2010000489), JSPS KAKENHI (22580112), and Syngenta Ltd. (2008-Hebei Medical University-Syngenta-02) is gratefully acknowledged. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2013/1

Y1 - 2013/1

N2 - A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

AB - A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

KW - Achillea millefolium

KW - Compositae

KW - antiproliferative activity

KW - flavonoids

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SN - 0009-3130

VL - 48

SP - 958

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JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

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ER -

Cytotoxic flavonoids from the flowers of Achillea millefolium

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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