Cytotoxic flavonoids from the flowers of Achillea millefolium

Chang Hong Huo, Yong Li, Man Li Zhang, Yu Fang Wang, Qing Zhang, Fang Qin, Qing Wen Shi, Hiromasa Kiyota

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

Original languageEnglish
Pages (from-to)958-962
Number of pages5
JournalChemistry of Natural Compounds
Volume48
Issue number6
DOIs
Publication statusPublished - Jan 2013
Externally publishedYes

Fingerprint

Achillea millefolium
flavonoids
cell lines
flowers
prostatic neoplasms
breast neoplasms
spectral analysis
neoplasm cells

Keywords

  • Achillea millefolium
  • antiproliferative activity
  • Compositae
  • flavonoids

ASJC Scopus subject areas

  • Plant Science

Cite this

Cytotoxic flavonoids from the flowers of Achillea millefolium. / Huo, Chang Hong; Li, Yong; Zhang, Man Li; Wang, Yu Fang; Zhang, Qing; Qin, Fang; Shi, Qing Wen; Kiyota, Hiromasa.

In: Chemistry of Natural Compounds, Vol. 48, No. 6, 01.2013, p. 958-962.

Research output: Contribution to journalArticle

Huo, CH, Li, Y, Zhang, ML, Wang, YF, Zhang, Q, Qin, F, Shi, QW & Kiyota, H 2013, 'Cytotoxic flavonoids from the flowers of Achillea millefolium', Chemistry of Natural Compounds, vol. 48, no. 6, pp. 958-962. https://doi.org/10.1007/s10600-013-0438-y
Huo, Chang Hong ; Li, Yong ; Zhang, Man Li ; Wang, Yu Fang ; Zhang, Qing ; Qin, Fang ; Shi, Qing Wen ; Kiyota, Hiromasa. / Cytotoxic flavonoids from the flowers of Achillea millefolium. In: Chemistry of Natural Compounds. 2013 ; Vol. 48, No. 6. pp. 958-962.
@article{5639a41acab44a12a745785ac53bf1a4,
title = "Cytotoxic flavonoids from the flowers of Achillea millefolium",
abstract = "A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.",
keywords = "Achillea millefolium, antiproliferative activity, Compositae, flavonoids",
author = "Huo, {Chang Hong} and Yong Li and Zhang, {Man Li} and Wang, {Yu Fang} and Qing Zhang and Fang Qin and Shi, {Qing Wen} and Hiromasa Kiyota",
year = "2013",
month = "1",
doi = "10.1007/s10600-013-0438-y",
language = "English",
volume = "48",
pages = "958--962",
journal = "Chemistry of Natural Compounds",
issn = "0009-3130",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Cytotoxic flavonoids from the flowers of Achillea millefolium

AU - Huo, Chang Hong

AU - Li, Yong

AU - Zhang, Man Li

AU - Wang, Yu Fang

AU - Zhang, Qing

AU - Qin, Fang

AU - Shi, Qing Wen

AU - Kiyota, Hiromasa

PY - 2013/1

Y1 - 2013/1

N2 - A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

AB - A new natural product, 8,8'-bi-3-O-methylquercetin (9), and eight known flavonoids were isolated from the flowers of Achillea millefolium. Their structures were established on the basis of spectral evidence. All the spectral data of these compounds were reassigned after interpretation of their 2D NMR spectroscopic data. Compounds 2, 5, and 7 exhibited antiproliferative activity against human breast cancer cell line MCF7WT. In addition, 2 and 5 showed antiproliferative activity against human prostatic cancer cell line PC-3, while the other compounds did not show inhibitory effects in two human tumor cell lines tested.

KW - Achillea millefolium

KW - antiproliferative activity

KW - Compositae

KW - flavonoids

UR - http://www.scopus.com/inward/record.url?scp=84874447825&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874447825&partnerID=8YFLogxK

U2 - 10.1007/s10600-013-0438-y

DO - 10.1007/s10600-013-0438-y

M3 - Article

VL - 48

SP - 958

EP - 962

JO - Chemistry of Natural Compounds

JF - Chemistry of Natural Compounds

SN - 0009-3130

IS - 6

ER -