Cytotoxic effects of alcohol extracts from a plastic wrap (polyvinylidene chloride) on human cultured liver cells and mouse primary cultured liver cells

Ken Ichi Yamamoto, Hiroko Kagawa, Sakae Arimoto, Xian Wen Tan, Kento Yasui, Toshiyuki Oshiki, Masayoshi Namba, Masakiyo Sakaguchi

Research output: Contribution to journalArticlepeer-review

Abstract

An increasing accumulation of microplastics and further degraded nanoplastics in our environment is suspected to have harmful effects on humans and animals. To clarify this problem, we tested the cytotoxicity of two types of plastic wrap on human cultured liver cells and mouse primary cultured liver cells. Alcohol extracts from plastic wrap, i.e., polyvinylidene chloride (PVDC), showed cytotoxic effects on the cells. Alcohol extracts of polyethylene (PE) wrap were not toxic. The commercially available PVDC wrap consists of vinylidene chloride, epoxidized soybean oil, epoxidized linseed oil as a stiffener and stabilizer; we sought to identify which component(s) are toxic. The epoxidized soybean oil and epoxidized linseed oil exerted strong cytotoxicity, but the plastic raw material itself, vinylidene chloride, did not. Our findings indicate that plastic wraps should be used with caution in order to prevent health risks.

Original languageEnglish
Pages (from-to)327-334
Number of pages8
JournalActa medica Okayama
Volume74
Issue number4
Publication statusPublished - 2020

Keywords

  • Cytotoxicity
  • In vitro
  • Liver cells
  • Plastic wrap
  • Plasticizer

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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