Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment

Masayuki Ito, Hiromasa Ohira, Masayuki Miyata, Tomohiro Suzuki, Yukio Sato, Shunji Kaise, Tomoe Nishimaki, Hiroshi Sakuma, Yoshimichi Nihei, Keiji Iwatsuki, Reiji Kasukawa

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

In a 31-year-old Japanese man with cytophagic histiocytic panniculitis (CHP) remission was achieved by a combination of combined chemotherapy CHOP and cyclosporin A treatment. He was admitted to our hospital in January 1994 with recurrent high fever of 40.2°C and tender and violaceous subcutaneous nodules on his trunk, arms and legs. He developed pancytopenia, hemorrhagic diathesis, liver dysfunction. Histological examination of the biopsied subcutaneous nodule revealed a lobular panniculitis with fat necrosis and a massive infiltration of histiocytes phagocytosing nuclear debris. He was treated initially with 40 mg/day prednisolone. However, following a reduction in prednisolone dosage, his symptoms reappeared. CHOP (cyclophosphamide, doxorubicin, vincristine and prednisolone) therapy was then initiated. Three courses of CHOP treatment alleviated his symptoms and cyclosporin A was used to maintain his condition for 15 months. His medication was then discontinued and he has been in complete remission for 10 months. Combined treatment of cyclosporin A and CHOP combined chemotherapy was shown to be effective for this patient with severe CHP.

Original languageEnglish
Pages (from-to)296-301
Number of pages6
JournalInternal Medicine
Volume38
Issue number3
Publication statusPublished - Mar 1999
Externally publishedYes

Fingerprint

Panniculitis
Cyclosporine
Prednisolone
Fat Necrosis
Hemorrhagic Disorders
Pancytopenia
Histiocytes
Vincristine
Therapeutics
Combination Drug Therapy
Phagocytosis
Doxorubicin
Cyclophosphamide
Liver Diseases
Leg
Arm
Fever
Drug Therapy

Keywords

  • Homophagocytic syndrome
  • Panniculitis
  • T cell disorder

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Ito, M., Ohira, H., Miyata, M., Suzuki, T., Sato, Y., Kaise, S., ... Kasukawa, R. (1999). Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment. Internal Medicine, 38(3), 296-301.

Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment. / Ito, Masayuki; Ohira, Hiromasa; Miyata, Masayuki; Suzuki, Tomohiro; Sato, Yukio; Kaise, Shunji; Nishimaki, Tomoe; Sakuma, Hiroshi; Nihei, Yoshimichi; Iwatsuki, Keiji; Kasukawa, Reiji.

In: Internal Medicine, Vol. 38, No. 3, 03.1999, p. 296-301.

Research output: Contribution to journalArticle

Ito, M, Ohira, H, Miyata, M, Suzuki, T, Sato, Y, Kaise, S, Nishimaki, T, Sakuma, H, Nihei, Y, Iwatsuki, K & Kasukawa, R 1999, 'Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment', Internal Medicine, vol. 38, no. 3, pp. 296-301.
Ito M, Ohira H, Miyata M, Suzuki T, Sato Y, Kaise S et al. Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment. Internal Medicine. 1999 Mar;38(3):296-301.
Ito, Masayuki ; Ohira, Hiromasa ; Miyata, Masayuki ; Suzuki, Tomohiro ; Sato, Yukio ; Kaise, Shunji ; Nishimaki, Tomoe ; Sakuma, Hiroshi ; Nihei, Yoshimichi ; Iwatsuki, Keiji ; Kasukawa, Reiji. / Cytophagic histiocytic panniculitis improved by combined CHOP and cyclosporin A treatment. In: Internal Medicine. 1999 ; Vol. 38, No. 3. pp. 296-301.
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