Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease

Saifun Nahar, Yoshiki Nakashima, Chika Miyagi-Shiohira, Takao Kinjo, Zensei Toyoda, Naoya Kobayashi, Issei Saitoh, Masami Watanabe, Hirofumi Noguchi, Jiro Fujita

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Adipose-derived mesenchymal stem cells (ADSCs) are a treatment cell source for patients with chronic liver injury. ADSCs are characterized by being harvested from the patient's own subcutaneous adipose tissue, a high cell yield (i.e., reduced immune rejection response), accumulation at a disease nidus, suppression of excessive immune response, production of various growth factors and cytokines, angiogenic effects, antiapoptotic effects, and control of immune cells via cellcell interaction. We previously showed that conditioned medium of ADSCs promoted hepatocyte proliferation and improved the liver function in a mouse model of acute liver failure. Furthermore, as found by many other groups, the administration of ADSCs improved liver tissue fibrosis in a mouse model of liver cirrhosis. A comprehensive protein expression analysis by liquid chromatography with tandem mass spectrometry showed that the various cytokines and chemokines produced by ADSCs promote the healing of liver disease. In this review, we examine the ability of expressed protein components of ADSCs to promote healing in cell therapy for liver disease. Previous studies demonstrated that ADSCs are a treatment cell source for patients with chronic liver injury. This review describes the various cytokines and chemokines produced by ADSCs that promote the healing of liver disease.

Original languageEnglish
Pages (from-to)146-159
Number of pages14
JournalWorld Journal of Stem Cells
Volume10
Issue number11
DOIs
Publication statusPublished - Nov 1 2018

Keywords

  • Adipose-derived mesenchymal stem cells
  • Cell transplantation therapy
  • Cytokine
  • Hepatocytes
  • Liquid chromatography with tandem mass spectrometry
  • Liver cirrhosis

ASJC Scopus subject areas

  • Histology
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cell Biology

Fingerprint Dive into the research topics of 'Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease'. Together they form a unique fingerprint.

  • Cite this

    Nahar, S., Nakashima, Y., Miyagi-Shiohira, C., Kinjo, T., Toyoda, Z., Kobayashi, N., Saitoh, I., Watanabe, M., Noguchi, H., & Fujita, J. (2018). Cytokines in adipose-derived mesenchymal stem cells promote the healing of liver disease. World Journal of Stem Cells, 10(11), 146-159. https://doi.org/10.4252/wjsc.v10.i11.146