Cytokines and chemokines: Roles in the pathophysiology and therapy of ischemia and reperfusion injury

Motoo Araki, Austin D. Schenk, Robert L. Fairchild

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

The understanding of ischemia and reperfusion injury grows, but the search for the critical early regulators of the ischemia and reperfusion injury process remains difficult. The current therapies to attenuate ischemia and reperfusion injury are overwhelming, but the subtleties of the injury and of human medicine prevent immediate clinical implementation. Cytokineand chemokine-targeted therapies to circumvent ischemia and reperfusion injury in transplanted organs hold promise for the future.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalCurrent Opinion in Organ Transplantation
Volume9
Issue number2
DOIs
Publication statusPublished - Jan 1 2004
Externally publishedYes

Keywords

  • Chemokines
  • Cytokines
  • Ischemia and reperfusion injury
  • Macrophages
  • Neutrophils

ASJC Scopus subject areas

  • Immunology and Allergy
  • Transplantation

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