Cytogenetic and functional studies of leukocytes with pelger-huët anomaly

Tomoaki Matsumoto, Y. Harada, K. Yamaguchi, H. Matsuzaki, I. Sanada, Teizo Yoshimura, M. Honda, R. Tanaka

Research output: Contribution to journalArticle

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Abstract

A cytogenetic study was undertaken in 15 cases of Pelger-Huët (P-H) anomaly in 3 families. An enlarged short arm of chromosome 22 (22p+) was found in 14 cases, but in these families 4 cases without P-H anomaly did not show 22p+ in the karyotype. In P-H anomaly, delayed skin hypersensitivity reactions, levels of serum IgG, IgM and IgA, lymphocyte subpopulations, and natural killer and antibody-dependent, cell-mediated cytotoxicity activities were within normal range. The level of serum IgE, mitogen responses in peripheral blood lymphocyte and plaque-forming cell counts were also within normal range with the exception of a case with atopic eczema. Enzymatic activities, nitroblue tetrazolium reduction and phagocytic capacities of neutrophils appeared normal. Abnormalities of neutrophils in cases of P-H anomaly, as compared with normal subjects, were also negative in examinations for chemotaxis and spontaneous migration under agarose and in a membrane filter.

Original languageEnglish
Pages (from-to)264-273
Number of pages10
JournalActa Haematologica
Volume72
Issue number4
Publication statusPublished - 1984
Externally publishedYes

Fingerprint

Cytogenetics
Reference Values
Neutrophils
Leukocytes
Antibody-Dependent Cell Cytotoxicity
Nitroblue Tetrazolium
Chromosomes, Human, Pair 22
Lymphocyte Subsets
Delayed Hypersensitivity
Chemotaxis
Atopic Dermatitis
Serum
Karyotype
Mitogens
Sepharose
Immunoglobulin A
Immunoglobulin E
Immunoglobulin M
Cell Count
Immunoglobulin G

Keywords

  • Chromosome 22p<sup>+</sup>
  • Lymphocyte functions
  • Neutrophil functions
  • Pelger-Huët anomaly

ASJC Scopus subject areas

  • Hematology

Cite this

Matsumoto, T., Harada, Y., Yamaguchi, K., Matsuzaki, H., Sanada, I., Yoshimura, T., ... Tanaka, R. (1984). Cytogenetic and functional studies of leukocytes with pelger-huët anomaly. Acta Haematologica, 72(4), 264-273.

Cytogenetic and functional studies of leukocytes with pelger-huët anomaly. / Matsumoto, Tomoaki; Harada, Y.; Yamaguchi, K.; Matsuzaki, H.; Sanada, I.; Yoshimura, Teizo; Honda, M.; Tanaka, R.

In: Acta Haematologica, Vol. 72, No. 4, 1984, p. 264-273.

Research output: Contribution to journalArticle

Matsumoto, T, Harada, Y, Yamaguchi, K, Matsuzaki, H, Sanada, I, Yoshimura, T, Honda, M & Tanaka, R 1984, 'Cytogenetic and functional studies of leukocytes with pelger-huët anomaly', Acta Haematologica, vol. 72, no. 4, pp. 264-273.
Matsumoto T, Harada Y, Yamaguchi K, Matsuzaki H, Sanada I, Yoshimura T et al. Cytogenetic and functional studies of leukocytes with pelger-huët anomaly. Acta Haematologica. 1984;72(4):264-273.
Matsumoto, Tomoaki ; Harada, Y. ; Yamaguchi, K. ; Matsuzaki, H. ; Sanada, I. ; Yoshimura, Teizo ; Honda, M. ; Tanaka, R. / Cytogenetic and functional studies of leukocytes with pelger-huët anomaly. In: Acta Haematologica. 1984 ; Vol. 72, No. 4. pp. 264-273.
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