Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

Original languageEnglish
Pages (from-to)72-76
Number of pages5
JournalNippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan
Volume114
Issue number1325
DOIs
Publication statusPublished - Jan 2006

Fingerprint

Silicone Elastomers
silicones
elastomers
Elastomers
Silicones
Contact angle
Cells
Emulsion polymerization
fibroblasts
Fibroblasts
wettability
cells
emulsions
Wetting
polymerization
methacryloxypropyltrimethoxysilane
Water
water

Keywords

  • γ-methacryloxypropyltri-methoxysilane
  • Cytocompatibility
  • Emulsion polymerization
  • Grafting
  • Silicone
  • Surface modification

ASJC Scopus subject areas

  • Ceramics and Composites

Cite this

Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane. / Shirosaki, Yuki; Tsuru, Kanji; Hayakawa, Satoshi; Osaka, Akiyoshi; Takashima, Seisuke.

In: Nippon Seramikkusu Kyokai Gakujutsu Ronbunshi/Journal of the Ceramic Society of Japan, Vol. 114, No. 1325, 01.2006, p. 72-76.

Research output: Contribution to journalArticle

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