Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki; Kanji Tsuru; Satoshi Hayakawa; Akiyoshi Osaka; Seisuke Takashima

doi:10.2109/jcersj.114.72

Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Yuki Shirosaki, Kanji Tsuru, Satoshi Hayakawa, Akiyoshi Osaka, Seisuke Takashima

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

Original language	English
Pages (from-to)	72-76
Number of pages	5
Journal	Journal of the Ceramic Society of Japan
Volume	114
Issue number	1325
DOIs	https://doi.org/10.2109/jcersj.114.72
Publication status	Published - Jan 2006

Keywords

Cytocompatibility
Emulsion polymerization
Grafting
Silicone
Surface modification
γ-methacryloxypropyltri-methoxysilane

ASJC Scopus subject areas

Ceramics and Composites
Chemistry(all)
Condensed Matter Physics
Materials Chemistry

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10.2109/jcersj.114.72

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title = "Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane",

abstract = "γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.",

keywords = "Cytocompatibility, Emulsion polymerization, Grafting, Silicone, Surface modification, γ-methacryloxypropyltri-methoxysilane",

author = "Yuki Shirosaki and Kanji Tsuru and Satoshi Hayakawa and Akiyoshi Osaka and Seisuke Takashima",

year = "2006",

month = jan,

doi = "10.2109/jcersj.114.72",

language = "English",

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T1 - Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

AU - Shirosaki, Yuki

AU - Tsuru, Kanji

AU - Hayakawa, Satoshi

AU - Osaka, Akiyoshi

AU - Takashima, Seisuke

PY - 2006/1

Y1 - 2006/1

N2 - γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

AB - γ-Methacryloxypropyltrimethoxysilane (γ-MPS) was grafted on a silicone elastomer by emulsion polymerization in order to improve cytocompatibility. The wettability of the grafted surface was evaluated with a contact angle toward distilled water. By grafting within 30 min at 60°C, the contact angle was reduced from 110° to about 70° while it remained almost constant for longer grafting. A larger number of osteoblastic cells (MC3T3-E1) and fibroblast cells (1929) proliferated on the surface modified with γ-MPS compared with the original silicone surface. After culturing for 7 d, the cells completely covered the grafted surface and even formed a cell layer.

KW - Cytocompatibility

KW - Emulsion polymerization

KW - Grafting

KW - Silicone

KW - Surface modification

KW - γ-methacryloxypropyltri-methoxysilane

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Cytocompatibility of silicone elastomer grafted with γ-Methacryloxypropyltrimethoxysilane

Abstract

Keywords

ASJC Scopus subject areas

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