CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka

Zeki Topcu, Itsuo Chiba, Masaki Fujieda, Toshiyuki Shibata, Noritaka Ariyoshi, Hiroshi Yamazaki, Figen Sevgican, Malsantha Muthumala, Hiroshi Kobayashi, Tetsuya Kamataki

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

We investigated the relationship between inter-individual difference in CYP2A6 genotype and susceptibility to oral cancer among habitual betel quid chewers in a Sri Lanka population. A total of 286 subjects showing oral malignant or premalignant lesions and 135 control subjects with no lesions were analyzed. The frequency of homozygotes for CYP2A6*4C mutation, a gene deletion type of polymorphism, was significantly lower in the case subjects than the controls. The odds ratio (OR) of the group homozygous for the deletion was significantly lower and calculated to be 0.14 (95% CI; 0.03-0.72). In the allelic base analysis, there was also a significant decrease in the OR of the deletion allele. Our data suggest that deficient CYP2A6 activity due to genetic polymorphism reduces oral cancer risk in betel quid chewers.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalCarcinogenesis
Volume23
Issue number4
Publication statusPublished - 2002
Externally publishedYes

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Sri Lanka
Mouth Neoplasms
Gene Deletion
Odds Ratio
Homozygote
Genetic Polymorphisms
Individuality
Alleles
Genotype
Mutation
Population

ASJC Scopus subject areas

  • Cancer Research

Cite this

Topcu, Z., Chiba, I., Fujieda, M., Shibata, T., Ariyoshi, N., Yamazaki, H., ... Kamataki, T. (2002). CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. Carcinogenesis, 23(4), 595-598.

CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. / Topcu, Zeki; Chiba, Itsuo; Fujieda, Masaki; Shibata, Toshiyuki; Ariyoshi, Noritaka; Yamazaki, Hiroshi; Sevgican, Figen; Muthumala, Malsantha; Kobayashi, Hiroshi; Kamataki, Tetsuya.

In: Carcinogenesis, Vol. 23, No. 4, 2002, p. 595-598.

Research output: Contribution to journalArticle

Topcu, Z, Chiba, I, Fujieda, M, Shibata, T, Ariyoshi, N, Yamazaki, H, Sevgican, F, Muthumala, M, Kobayashi, H & Kamataki, T 2002, 'CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka', Carcinogenesis, vol. 23, no. 4, pp. 595-598.
Topcu Z, Chiba I, Fujieda M, Shibata T, Ariyoshi N, Yamazaki H et al. CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. Carcinogenesis. 2002;23(4):595-598.
Topcu, Zeki ; Chiba, Itsuo ; Fujieda, Masaki ; Shibata, Toshiyuki ; Ariyoshi, Noritaka ; Yamazaki, Hiroshi ; Sevgican, Figen ; Muthumala, Malsantha ; Kobayashi, Hiroshi ; Kamataki, Tetsuya. / CYP2A6 gene deletion reduces oral cancer risk in betel quid chewers in Sri Lanka. In: Carcinogenesis. 2002 ; Vol. 23, No. 4. pp. 595-598.
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