Abstract
Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
| Original language | English |
|---|---|
| Pages (from-to) | 532-534 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 22 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - May 1999 |
Keywords
- Antimalarial drug
- Chloroquine
- Cycloprodigiosin
- Malaria parasite
- Plasmodium falciparum
- Pseudoalteromonas denitrificans
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science
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Cite this
Kim, H. S., Hayashi, M., Shibata, Y., Wataya, Y., Mitamura, T., Horii, T., Kawauchi, K., Hirata, H., Tsuboi, S., & Moriyama, Y. (1999). Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. Biological and Pharmaceutical Bulletin, 22(5), 532-534. https://doi.org/10.1248/bpb.22.532