Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye Sook Kim; Mitsuko Hayashi; Yasuharu Shibata; Yusuke Wataya; Toshihide Mitamura; Toshihiro Horii; Keiko Kawauchi; Hajime Hirata; Seiji Tsuboi; Yoshinori Moriyama

doi:10.1248/bpb.22.532

Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye Sook Kim, Mitsuko Hayashi, Yasuharu Shibata, Yusuke Wataya, Toshihide Mitamura, Toshihiro Horii, Keiko Kawauchi, Hajime Hirata, Seiji Tsuboi, Yoshinori Moriyama

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

Original language	English
Pages (from-to)	532-534
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	22
Issue number	5
DOIs	https://doi.org/10.1248/bpb.22.532
Publication status	Published - May 1999

Keywords

Antimalarial drug
Chloroquine
Cycloprodigiosin
Malaria parasite
Plasmodium falciparum
Pseudoalteromonas denitrificans

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. / Kim, Hye Sook; Hayashi, Mitsuko; Shibata, Yasuharu; Wataya, Yusuke; Mitamura, Toshihide; Horii, Toshihiro; Kawauchi, Keiko; Hirata, Hajime; Tsuboi, Seiji; Moriyama, Yoshinori.

In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 5, 05.1999, p. 532-534.

Research output: Contribution to journal › Article › peer-review

Kim, Hye Sook ; Hayashi, Mitsuko ; Shibata, Yasuharu ; Wataya, Yusuke ; Mitamura, Toshihide ; Horii, Toshihiro ; Kawauchi, Keiko ; Hirata, Hajime ; Tsuboi, Seiji ; Moriyama, Yoshinori. / Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. In: Biological and Pharmaceutical Bulletin. 1999 ; Vol. 22, No. 5. pp. 532-534.

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abstract = "Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.",

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AU - Horii, Toshihiro

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