Abstract
Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
Original language | English |
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Pages (from-to) | 532-534 |
Number of pages | 3 |
Journal | Biological and Pharmaceutical Bulletin |
Volume | 22 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 1999 |
Keywords
- Antimalarial drug
- Chloroquine
- Cycloprodigiosin
- Malaria parasite
- Plasmodium falciparum
- Pseudoalteromonas denitrificans
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science