Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye Sook Kim; Mitsuko Hayashi; Yasuharu Shibata; Yusuke Wataya; Toshihide Mitamura; Toshihiro Horii; Keiko Kawauchi; Hajime Hirata; Seiji Tsuboi; Yoshinori Moriyama

doi:10.1248/bpb.22.532

Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye Sook Kim, Mitsuko Hayashi, Yasuharu Shibata, Yusuke Wataya, Toshihide Mitamura, Toshihiro Horii, Keiko Kawauchi, Hajime Hirata, Seiji Tsuboi, Yoshinori Moriyama

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

Abstract

Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

Original language	English
Pages (from-to)	532-534
Number of pages	3
Journal	Biological and Pharmaceutical Bulletin
Volume	22
Issue number	5
DOIs	https://doi.org/10.1248/bpb.22.532
Publication status	Published - May 1999

Keywords

Antimalarial drug
Chloroquine
Cycloprodigiosin
Malaria parasite
Plasmodium falciparum
Pseudoalteromonas denitrificans

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/bpb.22.532

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title = "Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent",

abstract = "Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.",

keywords = "Antimalarial drug, Chloroquine, Cycloprodigiosin, Malaria parasite, Plasmodium falciparum, Pseudoalteromonas denitrificans",

author = "Kim, {Hye Sook} and Mitsuko Hayashi and Yasuharu Shibata and Yusuke Wataya and Toshihide Mitamura and Toshihiro Horii and Keiko Kawauchi and Hajime Hirata and Seiji Tsuboi and Yoshinori Moriyama",

year = "1999",

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doi = "10.1248/bpb.22.532",

language = "English",

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T1 - Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

AU - Kim, Hye Sook

AU - Hayashi, Mitsuko

AU - Shibata, Yasuharu

AU - Wataya, Yusuke

AU - Mitamura, Toshihide

AU - Horii, Toshihiro

AU - Kawauchi, Keiko

AU - Hirata, Hajime

AU - Tsuboi, Seiji

AU - Moriyama, Yoshinori

PY - 1999/5

Y1 - 1999/5

N2 - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

AB - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

KW - Antimalarial drug

KW - Chloroquine

KW - Cycloprodigiosin

KW - Malaria parasite

KW - Plasmodium falciparum

KW - Pseudoalteromonas denitrificans

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Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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