Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye-Sook Kim, Mitsuko Hayashi, Yasuharu Shibata, Yusuke Wataya, Toshihide Mitamura, Toshihiro Horii, Keiko Kawauchi, Hajime Hirata, Seiji Tsuboi, Yoshinori Moriyama

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

Original languageEnglish
Pages (from-to)532-534
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number5
Publication statusPublished - May 1999

Fingerprint

Pseudoalteromonas
Antimalarials
Chloroquine
Plasmodium falciparum
Bacteria
cycloprodigiosin
Growth

Keywords

  • Antimalarial drug
  • Chloroquine
  • Cycloprodigiosin
  • Malaria parasite
  • Plasmodium falciparum
  • Pseudoalteromonas denitrificans

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Kim, H-S., Hayashi, M., Shibata, Y., Wataya, Y., Mitamura, T., Horii, T., ... Moriyama, Y. (1999). Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. Biological and Pharmaceutical Bulletin, 22(5), 532-534.

Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. / Kim, Hye-Sook; Hayashi, Mitsuko; Shibata, Yasuharu; Wataya, Yusuke; Mitamura, Toshihide; Horii, Toshihiro; Kawauchi, Keiko; Hirata, Hajime; Tsuboi, Seiji; Moriyama, Yoshinori.

In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 5, 05.1999, p. 532-534.

Research output: Contribution to journalArticle

Kim, H-S, Hayashi, M, Shibata, Y, Wataya, Y, Mitamura, T, Horii, T, Kawauchi, K, Hirata, H, Tsuboi, S & Moriyama, Y 1999, 'Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent', Biological and Pharmaceutical Bulletin, vol. 22, no. 5, pp. 532-534.
Kim, Hye-Sook ; Hayashi, Mitsuko ; Shibata, Yasuharu ; Wataya, Yusuke ; Mitamura, Toshihide ; Horii, Toshihiro ; Kawauchi, Keiko ; Hirata, Hajime ; Tsuboi, Seiji ; Moriyama, Yoshinori. / Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. In: Biological and Pharmaceutical Bulletin. 1999 ; Vol. 22, No. 5. pp. 532-534.
@article{5d5404500a614d4d86be2f80297dca79,
title = "Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent",
abstract = "Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50{\%} of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.",
keywords = "Antimalarial drug, Chloroquine, Cycloprodigiosin, Malaria parasite, Plasmodium falciparum, Pseudoalteromonas denitrificans",
author = "Hye-Sook Kim and Mitsuko Hayashi and Yasuharu Shibata and Yusuke Wataya and Toshihide Mitamura and Toshihiro Horii and Keiko Kawauchi and Hajime Hirata and Seiji Tsuboi and Yoshinori Moriyama",
year = "1999",
month = "5",
language = "English",
volume = "22",
pages = "532--534",
journal = "Biological and Pharmaceutical Bulletin",
issn = "0918-6158",
publisher = "Pharmaceutical Society of Japan",
number = "5",

}

TY - JOUR

T1 - Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

AU - Kim, Hye-Sook

AU - Hayashi, Mitsuko

AU - Shibata, Yasuharu

AU - Wataya, Yusuke

AU - Mitamura, Toshihide

AU - Horii, Toshihiro

AU - Kawauchi, Keiko

AU - Hirata, Hajime

AU - Tsuboi, Seiji

AU - Moriyama, Yoshinori

PY - 1999/5

Y1 - 1999/5

N2 - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

AB - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

KW - Antimalarial drug

KW - Chloroquine

KW - Cycloprodigiosin

KW - Malaria parasite

KW - Plasmodium falciparum

KW - Pseudoalteromonas denitrificans

UR - http://www.scopus.com/inward/record.url?scp=0033050149&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033050149&partnerID=8YFLogxK

M3 - Article

C2 - 10375177

AN - SCOPUS:0033050149

VL - 22

SP - 532

EP - 534

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

SN - 0918-6158

IS - 5

ER -