Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent

Hye Sook Kim, Mitsuko Hayashi, Yasuharu Shibata, Yusuke Wataya, Toshihide Mitamura, Toshihiro Horii, Keiko Kawauchi, Hajime Hirata, Seiji Tsuboi, Yoshinori Moriyama

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.

Original languageEnglish
Pages (from-to)532-534
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number5
DOIs
Publication statusPublished - May 1999

Keywords

  • Antimalarial drug
  • Chloroquine
  • Cycloprodigiosin
  • Malaria parasite
  • Plasmodium falciparum
  • Pseudoalteromonas denitrificans

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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  • Cite this

    Kim, H. S., Hayashi, M., Shibata, Y., Wataya, Y., Mitamura, T., Horii, T., Kawauchi, K., Hirata, H., Tsuboi, S., & Moriyama, Y. (1999). Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. Biological and Pharmaceutical Bulletin, 22(5), 532-534. https://doi.org/10.1248/bpb.22.532