Abstract
Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
| Original language | English |
|---|---|
| Pages (from-to) | 532-534 |
| Number of pages | 3 |
| Journal | Biological and Pharmaceutical Bulletin |
| Volume | 22 |
| Issue number | 5 |
| Publication status | Published - May 1999 |
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Keywords
- Antimalarial drug
- Chloroquine
- Cycloprodigiosin
- Malaria parasite
- Plasmodium falciparum
- Pseudoalteromonas denitrificans
ASJC Scopus subject areas
- Molecular Medicine
- Pharmacology, Toxicology and Pharmaceutics(all)
Cite this
Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent. / Kim, Hye-Sook; Hayashi, Mitsuko; Shibata, Yasuharu; Wataya, Yusuke; Mitamura, Toshihide; Horii, Toshihiro; Kawauchi, Keiko; Hirata, Hajime; Tsuboi, Seiji; Moriyama, Yoshinori.
In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 5, 05.1999, p. 532-534.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cycloprodigiosin hydrochloride obtained from Pseudoalteromonas denitrificans is a potent antimalarial agent
AU - Kim, Hye-Sook
AU - Hayashi, Mitsuko
AU - Shibata, Yasuharu
AU - Wataya, Yusuke
AU - Mitamura, Toshihide
AU - Horii, Toshihiro
AU - Kawauchi, Keiko
AU - Hirata, Hajime
AU - Tsuboi, Seiji
AU - Moriyama, Yoshinori
PY - 1999/5
Y1 - 1999/5
N2 - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
AB - Cycloprodigiosin hydrochloride (cPrG·HCl) is a stable fluorescent red pigment obtained from the marine bacterium Pseudoalteromonas denitrificans. It was found that the compound was incorporated into Plasmodium falciparum cells upon incubation and exhibited a potent antimalarial activity with the concentration required for 50% of the activity being 11 nM, which is stronger than that of chloroquine, a well-known antimalarial agent. The compound did not affect growth rate of mammalian cells. Antimalarial activity of cPrG·HCl was also observed in vivo. These results indicate that cPrG·HCl is a potent antimalarial drug.
KW - Antimalarial drug
KW - Chloroquine
KW - Cycloprodigiosin
KW - Malaria parasite
KW - Plasmodium falciparum
KW - Pseudoalteromonas denitrificans
UR - http://www.scopus.com/inward/record.url?scp=0033050149&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033050149&partnerID=8YFLogxK
M3 - Article
C2 - 10375177
AN - SCOPUS:0033050149
VL - 22
SP - 532
EP - 534
JO - Biological and Pharmaceutical Bulletin
JF - Biological and Pharmaceutical Bulletin
SN - 0918-6158
IS - 5
ER -