Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis

Masafumi Tokuoka, Tomoki Kikuchi, Yasutomo Shinohara, Akifumi Koyama, Shin Ichiro Iio, Takaaki Kubota, Jun'ichi Kobayashi, Yasuji Koyama, Akira Totsuka, Hitoshi Shindo, Kazuo Sato

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Speradine A is a derivative of cyclopiazonic acid (CPA) found in culture of an Aspergillus tamarii isolate. Heterologous expression of a predicted methyltransferase gene, cpaM, in the cpa biosynthesis gene cluster of A. tamarii resulted in the speradine A production in a 2-oxoCPA producing A. oryzae strain, indicating cpaM is involved in the speradine A biosynthesis.

Original languageEnglish
Pages (from-to)2081-2085
Number of pages5
JournalBioscience, Biotechnology and Biochemistry
Volume79
Issue number12
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Aspergillus oryzae
  • Cyclopiazonic acid
  • Secondary metabolism
  • Speradine A

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Cyclopiazonic acid biosynthesis gene cluster gene cpaM is required for speradine A biosynthesis'. Together they form a unique fingerprint.

Cite this