Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu; Yohei Muroya; Hiroki Kakuta; Hiroyuki Kagechika; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1248/cpb.51.1098

Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original language	English
Pages (from-to)	1098-1102
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	9
DOIs	https://doi.org/10.1248/cpb.51.1098
Publication status	Published - Sep 2003

Keywords

Cyclooxygenase
Inhibitor
Structure-activity relationship
Thalidomide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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title = "Cyclooxygenase inhibitors derived from thalidomide",

abstract = "Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.",

keywords = "Cyclooxygenase, Inhibitor, Structure-activity relationship, Thalidomide",

author = "Mamiko Suizu and Yohei Muroya and Hiroki Kakuta and Hiroyuki Kagechika and Aya Tanatani and Kazuo Nagasawa and Yuichi Hashimoto",

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AU - Suizu, Mamiko

AU - Muroya, Yohei

AU - Kakuta, Hiroki

AU - Kagechika, Hiroyuki

AU - Tanatani, Aya

AU - Nagasawa, Kazuo

AU - Hashimoto, Yuichi

PY - 2003/9

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KW - Inhibitor

KW - Structure-activity relationship

KW - Thalidomide

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