Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)

Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original languageEnglish
Pages (from-to)1098-1102
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number9
DOIs
Publication statusPublished - Sep 2003

Keywords

  • Cyclooxygenase
  • Inhibitor
  • Structure-activity relationship
  • Thalidomide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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