Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu; Yohei Muroya; Hiroki Kakuta; Hiroyuki Kagechika; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1248/cpb.51.1098

Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original language	English
Pages (from-to)	1098-1102
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	9
DOIs	https://doi.org/10.1248/cpb.51.1098
Publication status	Published - Sep 2003
Externally published	Yes

Keywords

Cyclooxygenase
Inhibitor
Structure-activity relationship
Thalidomide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Access to Document

10.1248/cpb.51.1098

Cite this

@article{6b704611ec574adb9a3dcf393c713eee,

title = "Cyclooxygenase inhibitors derived from thalidomide",

abstract = "Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.",

keywords = "Cyclooxygenase, Inhibitor, Structure-activity relationship, Thalidomide",

author = "Mamiko Suizu and Yohei Muroya and Hiroki Kakuta and Hiroyuki Kagechika and Aya Tanatani and Kazuo Nagasawa and Yuichi Hashimoto",

year = "2003",

month = sep,

doi = "10.1248/cpb.51.1098",

language = "English",

volume = "51",

pages = "1098--1102",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "9",

}

TY - JOUR

T1 - Cyclooxygenase inhibitors derived from thalidomide

AU - Suizu, Mamiko

AU - Muroya, Yohei

AU - Kakuta, Hiroki

AU - Kagechika, Hiroyuki

AU - Tanatani, Aya

AU - Nagasawa, Kazuo

AU - Hashimoto, Yuichi

PY - 2003/9

Y1 - 2003/9

N2 - Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

AB - Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

KW - Cyclooxygenase

KW - Inhibitor

KW - Structure-activity relationship

KW - Thalidomide

UR - http://www.scopus.com/inward/record.url?scp=2142640753&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=2142640753&partnerID=8YFLogxK

U2 - 10.1248/cpb.51.1098

DO - 10.1248/cpb.51.1098

M3 - Article

C2 - 12951457

AN - SCOPUS:2142640753

VL - 51

SP - 1098

EP - 1102

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

SN - 0009-2363

IS - 9

ER -

Cyclooxygenase inhibitors derived from thalidomide

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this