Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu; Yohei Muroya; Hiroki Kakuta; Hiroyuki Kagechika; Aya Tanatani; Kazuo Nagasawa; Yuichi Hashimoto

doi:10.1248/cpb.51.1098

Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original language	English
Pages (from-to)	1098-1102
Number of pages	5
Journal	Chemical and Pharmaceutical Bulletin
Volume	51
Issue number	9
DOIs	https://doi.org/10.1248/cpb.51.1098
Publication status	Published - Sep 2003
Externally published	Yes

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Keywords

Cyclooxygenase
Inhibitor
Structure-activity relationship
Thalidomide

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

Cite this

Suizu, M., Muroya, Y., Kakuta, H., Kagechika, H., Tanatani, A., Nagasawa, K., & Hashimoto, Y. (2003). Cyclooxygenase inhibitors derived from thalidomide. Chemical and Pharmaceutical Bulletin, 51(9), 1098-1102. https://doi.org/10.1248/cpb.51.1098

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AU - Nagasawa, Kazuo

AU - Hashimoto, Yuichi

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Access to Document

10.1248/cpb.51.1098