Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)


Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original languageEnglish
Pages (from-to)1098-1102
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Issue number9
Publication statusPublished - Sep 2003
Externally publishedYes


  • Cyclooxygenase
  • Inhibitor
  • Structure-activity relationship
  • Thalidomide

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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  • Cite this

    Suizu, M., Muroya, Y., Kakuta, H., Kagechika, H., Tanatani, A., Nagasawa, K., & Hashimoto, Y. (2003). Cyclooxygenase inhibitors derived from thalidomide. Chemical and Pharmaceutical Bulletin, 51(9), 1098-1102.