Cyclooxygenase inhibitors derived from thalidomide

Mamiko Suizu, Yohei Muroya, Hiroki Kakuta, Hiroyuki Kagechika, Aya Tanatani, Kazuo Nagasawa, Yuichi Hashimoto

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Several N-3,5-dimethylphenylphthalimide analogs possessing more potent cyclooxygenase-inhibiting activity than that of aspirin were prepared during structural development studies based on thalidomide. Substituent effects on the activity were investigated.

Original languageEnglish
Pages (from-to)1098-1102
Number of pages5
JournalChemical and Pharmaceutical Bulletin
Volume51
Issue number9
Publication statusPublished - Sep 2003
Externally publishedYes

Fingerprint

Thalidomide
Cyclooxygenase Inhibitors
Prostaglandin-Endoperoxide Synthases
Aspirin

Keywords

  • Cyclooxygenase
  • Inhibitor
  • Structure-activity relationship
  • Thalidomide

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Suizu, M., Muroya, Y., Kakuta, H., Kagechika, H., Tanatani, A., Nagasawa, K., & Hashimoto, Y. (2003). Cyclooxygenase inhibitors derived from thalidomide. Chemical and Pharmaceutical Bulletin, 51(9), 1098-1102.

Cyclooxygenase inhibitors derived from thalidomide. / Suizu, Mamiko; Muroya, Yohei; Kakuta, Hiroki; Kagechika, Hiroyuki; Tanatani, Aya; Nagasawa, Kazuo; Hashimoto, Yuichi.

In: Chemical and Pharmaceutical Bulletin, Vol. 51, No. 9, 09.2003, p. 1098-1102.

Research output: Contribution to journalArticle

Suizu, M, Muroya, Y, Kakuta, H, Kagechika, H, Tanatani, A, Nagasawa, K & Hashimoto, Y 2003, 'Cyclooxygenase inhibitors derived from thalidomide', Chemical and Pharmaceutical Bulletin, vol. 51, no. 9, pp. 1098-1102.
Suizu M, Muroya Y, Kakuta H, Kagechika H, Tanatani A, Nagasawa K et al. Cyclooxygenase inhibitors derived from thalidomide. Chemical and Pharmaceutical Bulletin. 2003 Sep;51(9):1098-1102.
Suizu, Mamiko ; Muroya, Yohei ; Kakuta, Hiroki ; Kagechika, Hiroyuki ; Tanatani, Aya ; Nagasawa, Kazuo ; Hashimoto, Yuichi. / Cyclooxygenase inhibitors derived from thalidomide. In: Chemical and Pharmaceutical Bulletin. 2003 ; Vol. 51, No. 9. pp. 1098-1102.
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