Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans

Osamu Yokota, Seishi Terada, Hideki Ishizu, Takeshi Ishihara, Hiroshi Ujike, Hanae Nakashima, Yoshihiko Nakashima, Aki Kugo, Frédéric Checler, Shigetoshi Kuroda

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We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Aβ deposition. These findings suggest that unknown factors besides Aβ deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.

Original languageEnglish
Pages (from-to)175-179
Number of pages5
JournalNeuroscience Letters
Issue number3
Publication statusPublished - Jun 12 2003



  • Alzheimer's disease
  • Cotton wool plaque
  • Cyclooxygenase-2
  • Hippocampus
  • Inflammation
  • Non-steroidal anti-inflammatory drugs

ASJC Scopus subject areas

  • Neuroscience(all)

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