TY - JOUR
T1 - Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans
AU - Yokota, Osamu
AU - Terada, Seishi
AU - Ishizu, Hideki
AU - Ishihara, Takeshi
AU - Ujike, Hiroshi
AU - Nakashima, Hanae
AU - Nakashima, Yoshihiko
AU - Kugo, Aki
AU - Checler, Frédéric
AU - Kuroda, Shigetoshi
N1 - Funding Information:
We thank Dr K. Tsuchiya for an insightful review of the manuscript and comments and Mr M. Kobashi and Ms M. Onbe for their excellent technical assistance. This work was supported in part by a research grant from the Zikei Institute of Psychiatry.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/6/12
Y1 - 2003/6/12
N2 - We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Aβ deposition. These findings suggest that unknown factors besides Aβ deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
AB - We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Aβ deposition. These findings suggest that unknown factors besides Aβ deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
KW - Alzheimer's disease
KW - Cotton wool plaque
KW - Cyclooxygenase-2
KW - Hippocampus
KW - Inflammation
KW - Non-steroidal anti-inflammatory drugs
UR - http://www.scopus.com/inward/record.url?scp=0037872107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037872107&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(03)00339-2
DO - 10.1016/S0304-3940(03)00339-2
M3 - Article
C2 - 12770691
AN - SCOPUS:0037872107
VL - 343
SP - 175
EP - 179
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -