TY - JOUR
T1 - Cyclooxygenase-2 in the hippocampus is up-regulated in Alzheimer's disease but not in variant Alzheimer's disease with cotton wool plaques in humans
AU - Yokota, Osamu
AU - Terada, Seishi
AU - Ishizu, Hideki
AU - Ishihara, Takeshi
AU - Ujike, Hiroshi
AU - Nakashima, Hanae
AU - Nakashima, Yoshihiko
AU - Kugo, Aki
AU - Checler, Frédéric
AU - Kuroda, Shigetoshi
PY - 2003/6/12
Y1 - 2003/6/12
N2 - We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Aβ deposition. These findings suggest that unknown factors besides Aβ deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
AB - We examined neuronal expression of cyclooxygenase-2, a pro-inflammatory protein, and neuron densities in the CA1-4 of the hippocampus in three cases of Alzheimer's disease with cotton wool plaques (CWP-AD), 17 cases of typical Alzheimer's disease without CWPs (tAD), and 26 normal controls. Cyclooxygenase-2 expression was significantly increased in all of the CA1-4 in tAD, but not in any subdivision in CWP-AD, compared with controls. Cyclooxygenase-2 expression in tAD was also significantly up-regulated compared with that in CWP-AD in all subdivisions. Furthermore, neuron density in the hippocampus was not significantly reduced in CWP-AD cases compared with controls despite remarkable intra- and extraneuronal Aβ deposition. These findings suggest that unknown factors besides Aβ deposition are necessary for the cyclooxygenase-2 up-regulation and neurodegeneration in Alzheimer's disease.
KW - Alzheimer's disease
KW - Cotton wool plaque
KW - Cyclooxygenase-2
KW - Hippocampus
KW - Inflammation
KW - Non-steroidal anti-inflammatory drugs
UR - http://www.scopus.com/inward/record.url?scp=0037872107&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037872107&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(03)00339-2
DO - 10.1016/S0304-3940(03)00339-2
M3 - Article
C2 - 12770691
AN - SCOPUS:0037872107
VL - 343
SP - 175
EP - 179
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -