Cyclic thrombocytopenia and polycythemia vera

K. Kojima, N. Fujii, E. Omoto, S. Nose, M. Yoneyama, Y. Sugii, H. Hiramatsu, M. Chikatsune, M. Sato, S. Takata, T. Itoshima, Mitsune Tanimoto

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9 Citations (Scopus)


A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We describe an unusual case of polycythemia vera in which the episodes of thrombocytopenia were followed regularly by thrombocytosis. The period of platelet count fluctuation was about 50 days, with the counts ranging from 34 to 820×1O9/l. Bone marrow megakaryocytes were decreased in number during platelet nadir. Circulating thrombopoietin levels fluctuated out of phase with the platelet count. We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalAnnals of Hematology
Issue number1
Publication statusPublished - Jan 1 2003


  • Chronic myeloproliferative disorder
  • Cyclic thrombocytopenia
  • Polycythemia vera
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


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