Cyclic thrombocytopenia and polycythemia vera

K. Kojima; N. Fujii; E. Omoto; S. Nose; M. Yoneyama; Y. Sugii; H. Hiramatsu; M. Chikatsune; M. Sato; S. Takata; T. Itoshima; Mitsune Tanimoto

doi:10.1007/s00277-002-0580-2

Cyclic thrombocytopenia and polycythemia vera

K. Kojima, N. Fujii, E. Omoto, S. Nose, M. Yoneyama, Y. Sugii, H. Hiramatsu, M. Chikatsune, M. Sato, S. Takata, T. Itoshima, Mitsune Tanimoto

University Hospital

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We describe an unusual case of polycythemia vera in which the episodes of thrombocytopenia were followed regularly by thrombocytosis. The period of platelet count fluctuation was about 50 days, with the counts ranging from 34 to 820×1O⁹/l. Bone marrow megakaryocytes were decreased in number during platelet nadir. Circulating thrombopoietin levels fluctuated out of phase with the platelet count. We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.

Original language	English
Pages (from-to)	61-63
Number of pages	3
Journal	Annals of Hematology
Volume	82
Issue number	1
DOIs	https://doi.org/10.1007/s00277-002-0580-2
Publication status	Published - Jan 1 2003

Keywords

Chronic myeloproliferative disorder
Cyclic thrombocytopenia
Polycythemia vera
Thrombopoietin

ASJC Scopus subject areas

Hematology

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10.1007/s00277-002-0580-2

Cite this

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title = "Cyclic thrombocytopenia and polycythemia vera",

abstract = "A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We describe an unusual case of polycythemia vera in which the episodes of thrombocytopenia were followed regularly by thrombocytosis. The period of platelet count fluctuation was about 50 days, with the counts ranging from 34 to 820×1O9/l. Bone marrow megakaryocytes were decreased in number during platelet nadir. Circulating thrombopoietin levels fluctuated out of phase with the platelet count. We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.",

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AU - Kojima, K.

AU - Fujii, N.

AU - Omoto, E.

AU - Nose, S.

AU - Yoneyama, M.

AU - Sugii, Y.

AU - Hiramatsu, H.

AU - Chikatsune, M.

AU - Sato, M.

AU - Takata, S.

AU - Itoshima, T.

AU - Tanimoto, Mitsune

PY - 2003/1/1

Y1 - 2003/1/1

N2 - A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We describe an unusual case of polycythemia vera in which the episodes of thrombocytopenia were followed regularly by thrombocytosis. The period of platelet count fluctuation was about 50 days, with the counts ranging from 34 to 820×1O9/l. Bone marrow megakaryocytes were decreased in number during platelet nadir. Circulating thrombopoietin levels fluctuated out of phase with the platelet count. We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.

AB - A periodic fall of platelet number characterizes an acquired pathological condition named cyclic thrombocytopenia. We describe an unusual case of polycythemia vera in which the episodes of thrombocytopenia were followed regularly by thrombocytosis. The period of platelet count fluctuation was about 50 days, with the counts ranging from 34 to 820×1O9/l. Bone marrow megakaryocytes were decreased in number during platelet nadir. Circulating thrombopoietin levels fluctuated out of phase with the platelet count. We suggest that at least some cases of polycythemia vera may have an unstable hematopoietic stem cell pool in nature, which could contribute to the development of unprovoked cyclic thrombocytopenia.

KW - Chronic myeloproliferative disorder

KW - Cyclic thrombocytopenia

KW - Polycythemia vera

KW - Thrombopoietin

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Cyclic thrombocytopenia and polycythemia vera

Abstract

Keywords

ASJC Scopus subject areas

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