Cutting edge: Acute lung allograft rejection is independent of secondary lymphoid organs

Andrew E. Gelman, Wenjun Li, Steven B. Richardson, Bernd H. Zinselmeyer, Jiaming Lai, Mikio Okazaki, Christopher G. Kornfeld, Friederike H. Kreisel, Seiichiro Sugimoto, Jeremy R. Tietjens, John Dempster, G. Alexander Patterson, Alexander S. Krupnick, Mark J. Miller, Daniel Kreisel

Research output: Contribution to journalArticlepeer-review

104 Citations (Scopus)


It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung transplantation. We show in this study that alloreactive T cells are initially primed within lung allografts and not in secondary lymphoid organs following transplantation. In contrast to other organs, lungs are acutely rejected in the absence of secondary lymphoid organs. Two-photon microscopy revealed that recipient T cells cluster predominantly around lung-resident, donor-derived CD11c+ cells early after engraftment. These findings demonstrate for the first time that alloimmune responses following lung transplantation are initiated in the graft itself and therefore identify a novel, potentially clinically relevant mechanism of lung allograft rejection.

Original languageEnglish
Pages (from-to)3969-3973
Number of pages5
JournalJournal of Immunology
Issue number7
Publication statusPublished - Apr 1 2009
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


Dive into the research topics of 'Cutting edge: Acute lung allograft rejection is independent of secondary lymphoid organs'. Together they form a unique fingerprint.

Cite this