Abstract
The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2-/- mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c + dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.
| Original language | English |
|---|---|
| Pages (from-to) | 3331-3335 |
| Number of pages | 5 |
| Journal | Journal of Immunology |
| Volume | 184 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - Apr 1 2010 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Immunology
- Medicine(all)
Cite this
Cutting edge : A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immune responses. / Chen, Keqiang; Le, Yingying; Liu, Ying; Gong, Wanghua; Ying, Guoguang; Huang, Jian; Yoshimura, Teizo; Tessarollo, Lino; Wang, Ji Ming.
In: Journal of Immunology, Vol. 184, No. 7, 01.04.2010, p. 3331-3335.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutting edge
T2 - A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immune responses
AU - Chen, Keqiang
AU - Le, Yingying
AU - Liu, Ying
AU - Gong, Wanghua
AU - Ying, Guoguang
AU - Huang, Jian
AU - Yoshimura, Teizo
AU - Tessarollo, Lino
AU - Wang, Ji Ming
PY - 2010/4/1
Y1 - 2010/4/1
N2 - The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2-/- mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c + dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.
AB - The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2-/- mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c + dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.
UR - http://www.scopus.com/inward/record.url?scp=77951644229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77951644229&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.0903022
DO - 10.4049/jimmunol.0903022
M3 - Article
C2 - 20200280
AN - SCOPUS:77951644229
VL - 184
SP - 3331
EP - 3335
JO - Journal of Immunology
JF - Journal of Immunology
SN - 0022-1767
IS - 7
ER -