Cutting edge: A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immune responses

Keqiang Chen, Yingying Le, Ying Liu, Wanghua Gong, Guoguang Ying, Jian Huang, Teizo Yoshimura, Lino Tessarollo, Ji Ming Wang

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

The formylpeptide receptor-like 1, now officially termed FPR2, in human and its mouse homolog mFPR2 mediate leukocyte migration in response to agonists associated with inflammation and immune responses. To clarify the in vivo role of the receptor, we generated mice deficient in mFPR2. mFPR2-/- mice showed markedly reduced severity in OVA/alum-induced allergic airway inflammation. This was associated with diminished recruitment of CD11c + dendritic cells into the airway mucosa and secondary lymphoid organs, as well as reduced production of Type 2 cytokines and Igs. We also found that the bronchoalveolar lavage fluid from wild type mice with airway inflammation contained mFPR2 agonist activity. This study reveals a critical role for mFPR2 in the progression of allergic airway inflammation and immune responses.

Original languageEnglish
Pages (from-to)3331-3335
Number of pages5
JournalJournal of Immunology
Volume184
Issue number7
DOIs
Publication statusPublished - Apr 1 2010
Externally publishedYes

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G-Protein-Coupled Receptors
Inflammation
Bronchoalveolar Lavage Fluid
Dendritic Cells
Mucous Membrane
Leukocytes
Cytokines

ASJC Scopus subject areas

  • Immunology
  • Medicine(all)

Cite this

Cutting edge : A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immune responses. / Chen, Keqiang; Le, Yingying; Liu, Ying; Gong, Wanghua; Ying, Guoguang; Huang, Jian; Yoshimura, Teizo; Tessarollo, Lino; Wang, Ji Ming.

In: Journal of Immunology, Vol. 184, No. 7, 01.04.2010, p. 3331-3335.

Research output: Contribution to journalArticle

Chen, Keqiang ; Le, Yingying ; Liu, Ying ; Gong, Wanghua ; Ying, Guoguang ; Huang, Jian ; Yoshimura, Teizo ; Tessarollo, Lino ; Wang, Ji Ming. / Cutting edge : A critical role for the G protein-coupled receptor mFPR2 in airway inflammation and immune responses. In: Journal of Immunology. 2010 ; Vol. 184, No. 7. pp. 3331-3335.
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