Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: A clinical overview

Keiji Iwatsuki; Zigang Xu; Mikio Ohtsuka; Fumio Kaneko

doi:10.1016/S0923-1811(99)00084-5

Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: A clinical overview

Keiji Iwatsuki, Zigang Xu, Mikio Ohtsuka, Fumio Kaneko

Graduate School of Medicine Dentistry and Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original language	English
Pages (from-to)	181-195
Number of pages	15
Journal	Journal of dermatological science
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/S0923-1811(99)00084-5
Publication status	Published - Apr 2000

Keywords

Cutaneous lymphoproliferative disorders
Epstein-Barr virus
Hydroa vacciniforme
Infectious mononucleosis
NK cell lymphoma

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Dermatology

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Cite this

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title = "Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection: A clinical overview",

abstract = "Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.",

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author = "Keiji Iwatsuki and Zigang Xu and Mikio Ohtsuka and Fumio Kaneko",

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