TY - JOUR
T1 - Cutaneous lymphoproliferative disorders associated with Epstein-Barr virus infection
T2 - A clinical overview
AU - Iwatsuki, Keiji
AU - Xu, Zigang
AU - Ohtsuka, Mikio
AU - Kaneko, Fumio
N1 - Funding Information:
We thank for generous donation of tissue sections from the following institutes: Departments of Dermatology, Kanazawa University (Dr M. Takata), Tohoku University (Drs H. Tagami, M. Iguchi, N. Tabata, and M. Tanaka), Sapporo Medical College (Dr S. Sugiyama), Aichi Medical College (Drs T. Ikeya, and Y. Nitta), Teikyo University (Dr I. Ando), Ohita Medical College (Drs S. Takayasu and H. Terashi), Yamaguchi Red-Cross Hospital (Dr K. Nishioka), Fujinomiya General Hospital (Drs H. Igarashi, and A. Aranami), Shirakawa Welfare Hospital (Dr H. Takenoshita), Japanese Red Cross Medical Center (Dr T. Shishiba) and Nihonkai Hospital (Dr S. Anzai), Department of Medicine, Tokyo Medical College (Dr Y. Katsura), Keio University (Dr T. Nishikawa), Asahikawa Medical College (Dr A. Yamamoto), Akita University (Dr S. Okada), Yamanashi Medical College (Drs S. Shimada, and K. Imada), Ehime University (Drs K. Hashimoto, and Y. Noma), Hakodate City (Dr C. Yashima), National Defence Medical College (Drs H. Takasu), Kyoto Prefectural University of Medicine (Drs K. Yamanishi, and R. Inada), Sendai City Hospital (Dr A. Sakakibara), and St. John's Institute, St. Thomas' Hospital (Dr Robin Russell-Jones). This study was supported in part by grants, no. 09670890, 11670843 (K. Iwatsuki), no. 10770417 (M. Ohtsuka) from the Ministry of Education, Science and Culture of Japan, Shiseido Basic Medical Research Fund (1998) (K. Iwatsuki), and Fukushima Society for the Promotion of Medicine (Z. Xu).
PY - 2000/4
Y1 - 2000/4
N2 - Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.
AB - Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.
KW - Cutaneous lymphoproliferative disorders
KW - Epstein-Barr virus
KW - Hydroa vacciniforme
KW - Infectious mononucleosis
KW - NK cell lymphoma
UR - http://www.scopus.com/inward/record.url?scp=0033956422&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033956422&partnerID=8YFLogxK
U2 - 10.1016/S0923-1811(99)00084-5
DO - 10.1016/S0923-1811(99)00084-5
M3 - Article
C2 - 10698155
AN - SCOPUS:0033956422
VL - 22
SP - 181
EP - 195
JO - Journal of Dermatological Science
JF - Journal of Dermatological Science
SN - 0923-1811
IS - 3
ER -
