Abstract
Epstein-Barr virus (EBV) infection is implicated in various kinds of neoplasms including certain types of cutaneous T or natural killer (NK) cell proliferative disorders. Although a pathogenic role of EBV infection is not clear, some EBV gene products expressed during a latency phase were found to have biological properties leading to cellular gene expression and immortalization. Furthermore, EBV can use an array of strategies host immune responses, and maintain the latent infection. EBV-associated cutaneous lymphoproliferative disorders are prevalent in Asia, and less frequent in western countries where infectious mononucleosis is common in adolescents and young adults. This review introduces recent advances on the mechanism of EBV infection, highlighting unique clinicopathologic manifestations of EBV-associated cutaneous lymphoproliferative disorders. Copyright (C) 2000 Elsevier Science Ireland Ltd.
Original language | English |
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Pages (from-to) | 181-195 |
Number of pages | 15 |
Journal | Journal of dermatological science |
Volume | 22 |
Issue number | 3 |
DOIs | |
Publication status | Published - Apr 2000 |
Keywords
- Cutaneous lymphoproliferative disorders
- Epstein-Barr virus
- Hydroa vacciniforme
- Infectious mononucleosis
- NK cell lymphoma
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Dermatology