Abstract
Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA)+ cells in peripheral blood T and natural killer (NK) cells in 33 patients and evaluated its association with aGVHD. The CLA+ T-cell fraction often increased 3-7 days before the onset of aGVHD, and the maximum percentage of CLA+ T cells in grades II-IV aGVHD cases was significantly higher than that in grade 0 or I aGVHD (P+ T-cell percentage was set at 20%, any higher percentage was a significant risk for the development of severe aGVHD (P+ T-cell percentage was significantly correlated with a high body temperature, low percutaneous oxygen saturation, and fibrinogen/fibrin degradation product D-dimer level. The post-allo-SCT CLA+ T cells exhibited a high ability to produce IL-2 and IFN-γ, and may be the effectors and immunological markers for aGVHD. The CLA+ NK-cell-fraction steadily increased 2-4 weeks after allo-SCT but was not influenced by aGVHD. The CLA+ T-cell percentage may predict the development of severe aGVHD in clinical settings.
| Original language | English |
|---|---|
| Pages (from-to) | 863-873 |
| Number of pages | 11 |
| Journal | Bone Marrow Transplantation |
| Volume | 43 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - 2009 |
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ASJC Scopus subject areas
- Hematology
- Transplantation
Cite this
Cutaneous lymphocyte antigen-positive T cells may predict the development of acute GVHD : Alterations and differences of CLA+ T- and NK-cell fractions. / Tsuchiyama, J.; Yoshino, Tadashi; Saito, T.; Furukawa, T.; Ito, K.; Fuse, I.; Aizawa, Y.
In: Bone Marrow Transplantation, Vol. 43, No. 11, 2009, p. 863-873.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Cutaneous lymphocyte antigen-positive T cells may predict the development of acute GVHD
T2 - Alterations and differences of CLA+ T- and NK-cell fractions
AU - Tsuchiyama, J.
AU - Yoshino, Tadashi
AU - Saito, T.
AU - Furukawa, T.
AU - Ito, K.
AU - Fuse, I.
AU - Aizawa, Y.
PY - 2009
Y1 - 2009
N2 - Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA)+ cells in peripheral blood T and natural killer (NK) cells in 33 patients and evaluated its association with aGVHD. The CLA+ T-cell fraction often increased 3-7 days before the onset of aGVHD, and the maximum percentage of CLA+ T cells in grades II-IV aGVHD cases was significantly higher than that in grade 0 or I aGVHD (P+ T-cell percentage was set at 20%, any higher percentage was a significant risk for the development of severe aGVHD (P+ T-cell percentage was significantly correlated with a high body temperature, low percutaneous oxygen saturation, and fibrinogen/fibrin degradation product D-dimer level. The post-allo-SCT CLA+ T cells exhibited a high ability to produce IL-2 and IFN-γ, and may be the effectors and immunological markers for aGVHD. The CLA+ NK-cell-fraction steadily increased 2-4 weeks after allo-SCT but was not influenced by aGVHD. The CLA+ T-cell percentage may predict the development of severe aGVHD in clinical settings.
AB - Acute GVHD (aGVHD) is a serious complication after allogeneic SCT (allo-SCT). However, an adequate immunological index is not yet available for assessing its severity. We analyzed the fraction of cutaneous lymphocyte antigen (CLA)+ cells in peripheral blood T and natural killer (NK) cells in 33 patients and evaluated its association with aGVHD. The CLA+ T-cell fraction often increased 3-7 days before the onset of aGVHD, and the maximum percentage of CLA+ T cells in grades II-IV aGVHD cases was significantly higher than that in grade 0 or I aGVHD (P+ T-cell percentage was set at 20%, any higher percentage was a significant risk for the development of severe aGVHD (P+ T-cell percentage was significantly correlated with a high body temperature, low percutaneous oxygen saturation, and fibrinogen/fibrin degradation product D-dimer level. The post-allo-SCT CLA+ T cells exhibited a high ability to produce IL-2 and IFN-γ, and may be the effectors and immunological markers for aGVHD. The CLA+ NK-cell-fraction steadily increased 2-4 weeks after allo-SCT but was not influenced by aGVHD. The CLA+ T-cell percentage may predict the development of severe aGVHD in clinical settings.
UR - http://www.scopus.com/inward/record.url?scp=67549133159&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67549133159&partnerID=8YFLogxK
U2 - 10.1038/bmt.2008.392
DO - 10.1038/bmt.2008.392
M3 - Article
C2 - 19043457
AN - SCOPUS:67549133159
VL - 43
SP - 863
EP - 873
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 11
ER -