Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia

Fumio Otsuka, Toshio Ogura, Kazushi Nakao, Nobuhiko Hayakawa, Yukari Mimura, Takayoshi Yamauchi, Hirofumi Makino

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A 49-year-old woman with Cushing's syndrome due to unilateral adrenal hyperplasia is presented. She had developed obesity and menopause for 2 years, but no hypertension or hypertrichosis was observed. Although plasma adrenocorticotropin and serum cortisol levels were within normal ranges, the circadian rhythm has completely disappeared. Free thyroxine and triiodothyronine levels were decreased. Adrenocorticotropin did not respond to corticotropinreleasing hormone, and urinary excretion of 17-hydroxycorticosteroids was not suppressed by dexamethasone. Abdominal computed tomography and 131-Adosterol scintigraphy demonstrated a unilateral functioning mass in the left adrenal gland. The resected left adrenal mass was pathologically diagnosed as the rare condition of adrenocortical nodular hyperplasia.

Original languageEnglish
Pages (from-to)385-390
Number of pages6
JournalInternal Medicine
Volume37
Issue number4
Publication statusPublished - 1998

Fingerprint

Cushing Syndrome
Adrenocorticotropic Hormone
Hyperplasia
Adosterol
17-Hydroxycorticosteroids
Hypertrichosis
Triiodothyronine
Adrenal Glands
Menopause
Circadian Rhythm
Thyroxine
Radionuclide Imaging
Dexamethasone
Hydrocortisone
Reference Values
Obesity
Tomography
Hormones
Hypertension
Serum

Keywords

  • Adrenalectomy
  • Dexamethasone suppression test
  • Glucocorticoid
  • Thyroid

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Otsuka, F., Ogura, T., Nakao, K., Hayakawa, N., Mimura, Y., Yamauchi, T., & Makino, H. (1998). Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia. Internal Medicine, 37(4), 385-390.

Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia. / Otsuka, Fumio; Ogura, Toshio; Nakao, Kazushi; Hayakawa, Nobuhiko; Mimura, Yukari; Yamauchi, Takayoshi; Makino, Hirofumi.

In: Internal Medicine, Vol. 37, No. 4, 1998, p. 385-390.

Research output: Contribution to journalArticle

Otsuka, F, Ogura, T, Nakao, K, Hayakawa, N, Mimura, Y, Yamauchi, T & Makino, H 1998, 'Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia', Internal Medicine, vol. 37, no. 4, pp. 385-390.
Otsuka F, Ogura T, Nakao K, Hayakawa N, Mimura Y, Yamauchi T et al. Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia. Internal Medicine. 1998;37(4):385-390.
Otsuka, Fumio ; Ogura, Toshio ; Nakao, Kazushi ; Hayakawa, Nobuhiko ; Mimura, Yukari ; Yamauchi, Takayoshi ; Makino, Hirofumi. / Cushing's Syndrome due to Unilateral Adrenocortical Hyperplasia. In: Internal Medicine. 1998 ; Vol. 37, No. 4. pp. 385-390.
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