Current status and potential of living-donor lobar lung transplantation

Hiroshi Date, Masaomi Yamane, Shinichi Toyooka, Megumi Okazaki, Motoi Aoe, Yoshifumi Sano

Research output: Contribution to journalReview article

18 Citations (Scopus)

Abstract

Although cadaveric lung transplantation (CLT) offers acceptable prospects for 5-year survival, chronic rejection and donor shortages remain major problems. In an effort to address the donor shortage issue, living-donor lobar lung transplantations (LDLLT) have been performed in some institutions. As of 2006, LDLLT has been performed in approximately 300 patients worldwide. The survival appears to be similar to or better than International Society for Heart and Lung Transplantation registry data on CLT. Because of the possible serious complications after donor lobectomy, LDLLT should be performed only for very sick patients by a well-prepared program. This type of procedure can be applied to restrictive, obstructive, infectious, and hypertensive lung diseases for both pediatric and adult patients who would die soon otherwise.

Original languageEnglish
Pages (from-to)1433-1439
Number of pages7
JournalFrontiers in Bioscience
Volume13
Issue number4
DOIs
Publication statusPublished - May 2 2008

Keywords

  • Cadaveric lung transplantation
  • Living-donor lobar lung transplantation
  • Size matching

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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