Cumulative epigenetic abnormalities in host genes with viral and microbial infection during initiation and progression of malignant lymphoma/leukemia

Takashi Oka, Hiaki Sato, Mamoru Ouchida, Atae Utsunomiya, Tadashi Yoshino

Research output: Contribution to journalReview article

5 Citations (Scopus)


Although cancers have been thought to be predominantly driven by acquired genetic changes, it is becoming clear that microenvironment-mediated epigenetic alterations play important roles. Aberrant promoter hypermethylation is a prevalent phenomenon in human cancers as well as malignant lymphoma/leukemia. Tumor suppressor genes become frequent targets of aberrant hypermethylation in the course of gene-silencing due to the increased and deregulated DNA methyltransferases (DNMTs). The purpose of this article is to review the current status of knowledge about the contribution of cumulative epigenetic abnormalities of the host genes after microbial and virus infection to the crisis and progression of malignant lymphoma/leukemia. In addition, the relevance of this knowledge to malignant lymphoma/leukemia assessment, prevention and early detection will be discussed.

Original languageEnglish
Pages (from-to)568-581
Number of pages14
Issue number1
Publication statusPublished - Mar 1 2011



  • Epigenetics
  • H Pylori
  • HTLV-I
  • Leukemia
  • Lymphoma
  • Methylation
  • Progression

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this