TY - JOUR
T1 - CTRP3 plays an important role in the development of collagen-induced arthritis in mice
AU - Murayama, Masanori A.
AU - Kakuta, Shigeru
AU - Maruhashi, Takumi
AU - Shimizu, Kenji
AU - Seno, Akimasa
AU - Kubo, Sachiko
AU - Sato, Nozomi
AU - Saijo, Shinobu
AU - Hattori, Masahira
AU - Iwakura, Yoichiro
N1 - Funding Information:
We thank Dr. Masaru Okabe for providing of EGR-101 ES cell and Dr. Yuko Kimura and Wen-Chao Song for assistance with the complement activation assay. We thank Dr. Masato Nose and thank our laboratory members for kind cooperation, discussion and animal care. This work was supported by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and from the CREST program of the JST to Y.I., M.A.M. is a research assistant of the CREST program.
PY - 2014/1/3
Y1 - 2014/1/3
N2 - Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.
AB - Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.
KW - CTRP3
KW - Collagen-induced arthritis
KW - Rheumatoid arthritis
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U2 - 10.1016/j.bbrc.2013.11.040
DO - 10.1016/j.bbrc.2013.11.040
M3 - Article
C2 - 24269820
AN - SCOPUS:84890857830
VL - 443
SP - 42
EP - 48
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -