TY - JOUR
T1 - CTRP3 plays an important role in the development of collagen-induced arthritis in mice
AU - Murayama, Masanori A.
AU - Kakuta, Shigeru
AU - Maruhashi, Takumi
AU - Shimizu, Kenji
AU - Seno, Akimasa
AU - Kubo, Sachiko
AU - Sato, Nozomi
AU - Saijo, Shinobu
AU - Hattori, Masahira
AU - Iwakura, Yoichiro
PY - 2014/1/3
Y1 - 2014/1/3
N2 - Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.
AB - Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.
KW - CTRP3
KW - Collagen-induced arthritis
KW - Rheumatoid arthritis
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U2 - 10.1016/j.bbrc.2013.11.040
DO - 10.1016/j.bbrc.2013.11.040
M3 - Article
C2 - 24269820
AN - SCOPUS:84890857830
VL - 443
SP - 42
EP - 48
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 1
ER -