CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Masanori A. Murayama, Shigeru Kakuta, Takumi Maruhashi, Kenji Shimizu, Akimasa Seno, Sachiko Kubo, Nozomi Sato, Shinobu Saijo, Masahira Hattori, Yoichiro Iwakura

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number1
DOIs
Publication statusPublished - Jan 3 2014
Externally publishedYes

Fingerprint

Experimental Arthritis
Collagen
Proteins
Rheumatoid Arthritis
Collagen Type II
Medicine
Arthritis
Joints
Cytokines
Messenger RNA
Antibodies
Autoimmune Diseases
Incidence

Keywords

  • Collagen-induced arthritis
  • CTRP3
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

CTRP3 plays an important role in the development of collagen-induced arthritis in mice. / Murayama, Masanori A.; Kakuta, Shigeru; Maruhashi, Takumi; Shimizu, Kenji; Seno, Akimasa; Kubo, Sachiko; Sato, Nozomi; Saijo, Shinobu; Hattori, Masahira; Iwakura, Yoichiro.

In: Biochemical and Biophysical Research Communications, Vol. 443, No. 1, 03.01.2014, p. 42-48.

Research output: Contribution to journalArticle

Murayama, MA, Kakuta, S, Maruhashi, T, Shimizu, K, Seno, A, Kubo, S, Sato, N, Saijo, S, Hattori, M & Iwakura, Y 2014, 'CTRP3 plays an important role in the development of collagen-induced arthritis in mice', Biochemical and Biophysical Research Communications, vol. 443, no. 1, pp. 42-48. https://doi.org/10.1016/j.bbrc.2013.11.040
Murayama, Masanori A. ; Kakuta, Shigeru ; Maruhashi, Takumi ; Shimizu, Kenji ; Seno, Akimasa ; Kubo, Sachiko ; Sato, Nozomi ; Saijo, Shinobu ; Hattori, Masahira ; Iwakura, Yoichiro. / CTRP3 plays an important role in the development of collagen-induced arthritis in mice. In: Biochemical and Biophysical Research Communications. 2014 ; Vol. 443, No. 1. pp. 42-48.
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