CTRP3 plays an important role in the development of collagen-induced arthritis in mice

Masanori A. Murayama, Shigeru Kakuta, Takumi Maruhashi, Kenji Shimizu, Akimasa Seno, Sachiko Kubo, Nozomi Sato, Shinobu Saijo, Masahira Hattori, Yoichiro Iwakura

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28 Citations (Scopus)

Abstract

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease exhibited most commonly in joints. We found that the expression of C1qtnf3, which encodes C1q/TNF-related protein 3 (CTRP3), was highly increased in two mouse RA models with different etiology. To elucidate the pathogenic roles of CTRP3 in the development of arthritis, we generated C1qtnf3-/- mice and examined the development of collagen-induced arthritis in these mice. We found that the incidence and severity score was higher in C1qtnf3-/- mice compared with wild-type (WT) mice. Histopathology of the joints was also more severe in C1qtnf3-/- mice. The levels of antibodies against type II collagen and pro-inflammatory cytokine mRNAs in C1qtnf3-/- mice were higher than WT mice. These observations indicate that CTRP3 plays an important role in the development of autoimmune arthritis, suggesting CTRP3 as a possible medicine to treat RA.

Original languageEnglish
Pages (from-to)42-48
Number of pages7
JournalBiochemical and Biophysical Research Communications
Volume443
Issue number1
DOIs
Publication statusPublished - Jan 3 2014
Externally publishedYes

Keywords

  • CTRP3
  • Collagen-induced arthritis
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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  • Cite this

    Murayama, M. A., Kakuta, S., Maruhashi, T., Shimizu, K., Seno, A., Kubo, S., Sato, N., Saijo, S., Hattori, M., & Iwakura, Y. (2014). CTRP3 plays an important role in the development of collagen-induced arthritis in mice. Biochemical and Biophysical Research Communications, 443(1), 42-48. https://doi.org/10.1016/j.bbrc.2013.11.040