CSF flow dynamics in motor neuron disease

Kota Sato, Nobutoshi Morimoto, Tohru Matsuura, Yasuyuki Ohta, Masatoshi Tsunoda, Yoshio Ikeda, Koji Abe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To assess cerebrospinal fluid (CSF) flow dynamics involvement in the pathogenesis of amyotrophic lateral sclerosis (ALS), we conducted CSF flow studies on 40 individuals with motor neuron diseases (MNDs) including ALS, and 28 age-matched normal and disease [cervical spondylosis (CS)] controls. Methods: The CSF pulsatile velocity anterior to the cervical cord at level C5 during one heart beat was determined non-invasively by phase-contrast electrocardiography-triggered magnetic resonance imaging. Results: In MND, caudal CSF velocity peaked at 25% of the cardiac cycle after the R wave (UTc/RR), showing an increased delay in comparison to normal controls, while amplitude Hc was significantly larger than that in CS. Discussion: We conclude that CSF flow dynamics of MND differ from those of controls and may thus facilitate differentiation of MND from CS.

Original languageEnglish
Pages (from-to)512-517
Number of pages6
JournalNeurological Research
Volume34
Issue number5
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Motor Neuron Disease
Hydrodynamics
Cerebrospinal Fluid
Spondylosis
Amyotrophic Lateral Sclerosis
Electrocardiography
Magnetic Resonance Imaging

Keywords

  • Amyotrophic lateral sclerosis
  • Cerebrospinal fluid
  • Motor neuron disease
  • MRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Sato, K., Morimoto, N., Matsuura, T., Ohta, Y., Tsunoda, M., Ikeda, Y., & Abe, K. (2012). CSF flow dynamics in motor neuron disease. Neurological Research, 34(5), 512-517. https://doi.org/10.1179/1743132812Y.0000000043

CSF flow dynamics in motor neuron disease. / Sato, Kota; Morimoto, Nobutoshi; Matsuura, Tohru; Ohta, Yasuyuki; Tsunoda, Masatoshi; Ikeda, Yoshio; Abe, Koji.

In: Neurological Research, Vol. 34, No. 5, 06.2012, p. 512-517.

Research output: Contribution to journalArticle

Sato, K, Morimoto, N, Matsuura, T, Ohta, Y, Tsunoda, M, Ikeda, Y & Abe, K 2012, 'CSF flow dynamics in motor neuron disease', Neurological Research, vol. 34, no. 5, pp. 512-517. https://doi.org/10.1179/1743132812Y.0000000043
Sato K, Morimoto N, Matsuura T, Ohta Y, Tsunoda M, Ikeda Y et al. CSF flow dynamics in motor neuron disease. Neurological Research. 2012 Jun;34(5):512-517. https://doi.org/10.1179/1743132812Y.0000000043
Sato, Kota ; Morimoto, Nobutoshi ; Matsuura, Tohru ; Ohta, Yasuyuki ; Tsunoda, Masatoshi ; Ikeda, Yoshio ; Abe, Koji. / CSF flow dynamics in motor neuron disease. In: Neurological Research. 2012 ; Vol. 34, No. 5. pp. 512-517.
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