Crystals of the neurotrophins

Robert C. Robinson, Czeslaw Radziejewski, David I. Stuart, E. Yvonne Jones

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The neurotrophins show a high degree of amino acid sequence homology, share similar solution properties, and display distinct but parallel functionalities. Here we report the crystallization and preliminary X-ray characterization of three neurotrophins: brain-derived neurotrophin, neurotrophin 3, and the heterodimer between brain-derived neurotrophin and neurotrophin 4. These findings are related to other published crystal parameters for neurotrophins, leading to the observation that, although crystal packing is highly variant, neurotrophins share common solubilities with respect to crystal growth.

Original languageEnglish
Pages (from-to)973-977
Number of pages5
JournalProtein Science
Volume5
Issue number5
DOIs
Publication statusPublished - May 1996
Externally publishedYes

Keywords

  • Trk
  • crystallography
  • nerve growth factor
  • receptor

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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  • Cite this

    Robinson, R. C., Radziejewski, C., Stuart, D. I., & Jones, E. Y. (1996). Crystals of the neurotrophins. Protein Science, 5(5), 973-977. https://doi.org/10.1002/pro.5560050520