@inproceedings{bd9504bde05846c886d08c74a08d844c,
title = "Crystallographic approach to regenerated and pathological hard tissues",
abstract = "A dominant inorganic substance in hard tissue is known to be a biological apatite (BAp) nano-crystal which basically crystallizes in an anisotropic hep lattice, and the BAp c-axis is parallel to extended collagen fibrils. We applied the microbeam X-ray diffractometer system with an incident beam spot 100μm or 50μm in diameter to the original, regenerated and pathological hard tissues in order to analyze the preferential alignment of the BAp c-axis as a parameter of bone quality closely relating to the mechanical function. We conclude that the BAp orientational distribution in the hard tissues is a new measure to evaluate stress distribution in vivo, nano-scale microstructure and the related mechanical function, healing process of the regenerated bone and progress of the bone diseases.",
keywords = "Biological apatite, Bone, Bone regeneration, Crystal orientation, Microbeam X-ray diffraction, Osteoarthritis, Osteopetrosis, Osteoporosis, Pathological hard tissue, Tissue engineering, rBMP-2",
author = "Takayoshi Nakano and Takuya Ishimoto and Lee, {Jee Wook} and Yukichi Umakoshi and Masaya Yamamoto and Yasuhiko Tabata and Akio Kobayashi and Hiroyoshi Iwaki and Kunio Takaoka and Mariko Kawai and Toshio Yamamoto",
year = "2006",
doi = "10.4028/0-87849-996-2.255",
language = "English",
isbn = "0878499962",
series = "Materials Science Forum",
publisher = "Trans Tech Publications Ltd",
pages = "255--260",
booktitle = "Advanced Structural and Functional Materials Design - Proceedings of the International Symposium on Advanced Structural and Functional Materials Design, 2004",
note = "International Symposium on Advanced Structural and Functional Materials Design, 2004 ; Conference date: 10-11-2004 Through 12-11-2004",
}