Cryoablation of renal cell carcinoma for patients with stage 4 or 5 non-dialysis chronic kidney disease

Hideo Gobara, Atsuhiro Nakatsuka, Kanichiro Shimizu, Takashi Yamanaka, Yusuke Matsui, Toshihiro Iguchi, Takao Hiraki, Koichiro Yamakado

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the safety and efficacy of cryoablation for renal cell carcinoma (RCC) in patients with stage 4 or 5 non-dialysis chronic kidney disease (CKD). Materials and methods: This retrospective multicenter study included patients with maximum tumor diameter ≤ 4 cm, estimated glomerular filtration rate (eGFR) < 30 ml/min/1.73 m 2 , in whom cryoablation was performed percutaneously with curative intent between July 2011 and May 2016. Results: Of 541 patients who underwent renal tumor cryoablation, 17 (3.1%; 4 women, 13 men; mean age 70.1 ± 10.6 years) with stage 4 or 5 non-dialysis CKD were included in this study. The pre-cryoablation eGFR was 22.5 ± 6.3 ml/min/1.73 m 2 . The mean tumor diameter was 2.8 ± 0.7 cm. No Grade 3 or higher adverse events occurred post-cryoablation. The eGFR at each time point was significantly lower than that before treatment. One patient required hemodialysis initiation at 21 months post-procedure. None of the patients showed residual RCC at their last follow-up. Conclusion: Cryoablation of RCC is safe in patients with stage 4 or 5 non-dialysis CKD and yields treatment results comparable to those in patients without CKD. This treatment could be completed without the early initiation of hemodialysis after the procedure.

Original languageEnglish
JournalJapanese Journal of Radiology
DOIs
Publication statusPublished - Jan 1 2019

Keywords

  • Chronic kidney disease
  • Cryoablation
  • Kidney
  • Renal cell carcinoma
  • Stage 4

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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