Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice

K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura

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Abstract

Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

Original languageEnglish
Pages (from-to)945-947
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume39
Issue number11
DOIs
Publication statusPublished - Nov 1987

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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