Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice

K. Watanabe; S. Narimatsu; I. Yamamoto; H. Yoshimura

doi:10.1111/j.2042-7158.1987.tb03136.x

Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ⁸‐tetrahydrocannabinol and 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol in mice

K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Repeated administration (5 mg kg⁻¹ day⁻¹ i.v.) of Δ⁸‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ⁸‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ⁸‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

Original language	English
Pages (from-to)	945-947
Number of pages	3
Journal	Journal of Pharmacy and Pharmacology
Volume	39
Issue number	11
DOIs	https://doi.org/10.1111/j.2042-7158.1987.tb03136.x
Publication status	Published - Nov 1987

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

Access to Document

10.1111/j.2042-7158.1987.tb03136.x

Cite this

Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ⁸‐tetrahydrocannabinol and 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol in mice. / Watanabe, K.; Narimatsu, S.; Yamamoto, I.; Yoshimura, H.

In: Journal of Pharmacy and Pharmacology, Vol. 39, No. 11, 11.1987, p. 945-947.

Research output: Contribution to journal › Article › peer-review

@article{5240855ec63640febd9cfcd6057d5c8a,

title = "Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice",

abstract = "Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain",

author = "K. Watanabe and S. Narimatsu and I. Yamamoto and H. Yoshimura",

year = "1987",

month = nov,

doi = "10.1111/j.2042-7158.1987.tb03136.x",

language = "English",

volume = "39",

pages = "945--947",

journal = "Journal of Pharmacy and Pharmacology",

issn = "0022-3573",

publisher = "Pharmaceutical Press",

number = "11",

}

TY - JOUR

T1 - Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice

AU - Watanabe, K.

AU - Narimatsu, S.

AU - Yamamoto, I.

AU - Yoshimura, H.

PY - 1987/11

Y1 - 1987/11

N2 - Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

AB - Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

UR - http://www.scopus.com/inward/record.url?scp=0023547266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023547266&partnerID=8YFLogxK

U2 - 10.1111/j.2042-7158.1987.tb03136.x

DO - 10.1111/j.2042-7158.1987.tb03136.x

M3 - Article

C2 - 2892923

AN - SCOPUS:0023547266

VL - 39

SP - 945

EP - 947

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 11

ER -

Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ⁸‐tetrahydrocannabinol and 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol in mice

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this