Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ8‐tetrahydrocannabinol and 11‐hydroxy‐Δ8‐tetrahydrocannabinol in mice

K. Watanabe; S. Narimatsu; I. Yamamoto; H. Yoshimura

doi:10.1111/j.2042-7158.1987.tb03136.x

Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ⁸‐tetrahydrocannabinol and 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol in mice

K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura

Faculty of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Repeated administration (5 mg kg⁻¹ day⁻¹ i.v.) of Δ⁸‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ⁸‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ⁸‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

Original language	English
Pages (from-to)	945-947
Number of pages	3
Journal	Journal of Pharmacy and Pharmacology
Volume	39
Issue number	11
DOIs	https://doi.org/10.1111/j.2042-7158.1987.tb03136.x
Publication status	Published - Nov 1987

ASJC Scopus subject areas

Pharmacology
Pharmaceutical Science

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Cross‐tolerance development to the prolongation of pentobarbitone‐induced sleep by Δ⁸‐tetrahydrocannabinol and 11‐hydroxy‐Δ⁸‐tetrahydrocannabinol in mice. / Watanabe, K.; Narimatsu, S.; Yamamoto, I.; Yoshimura, H.

In: Journal of Pharmacy and Pharmacology, Vol. 39, No. 11, 11.1987, p. 945-947.

Research output: Contribution to journal › Article › peer-review

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abstract = "Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain",

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AB - Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain

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