Abstract
Repeated administration (5 mg kg−1 day−1 i.v.) of Δ8‐tetrahydrocannabinol and its active metabolite, 11‐hydroxy‐Δ8‐tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone‐induced sleep in mice. Reciprocal cross‐tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8‐tetrahydrocannabinol. The results suggest that 11‐hydroxy‐Δ8‐tetrahydrocannabinol plays an important role both in the sleep‐prolonging effect of Δ8‐tetrahydrocannabinol and its tolerance development. 1987 Royal Pharmaceutical Society of Great Britain
Original language | English |
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Pages (from-to) | 945-947 |
Number of pages | 3 |
Journal | Journal of Pharmacy and Pharmacology |
Volume | 39 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1987 |
ASJC Scopus subject areas
- Pharmacology
- Pharmaceutical Science