TY - JOUR
T1 - Crosstalk between Fas and S1P1 signaling via NF-kB in osteoclasts controls bone destruction in the TMJ due to rheumatoid arthritis
AU - Hutami, Islamy Rahma
AU - Tanaka, Eiji
AU - Izawa, Takashi
N1 - Funding Information:
This work was supported by the grants provided by JSPS KAKENHI (Grant Numbers. 25713063, 15K15757, 17K19758, 18H03011 to T.I.), The Ichiro Kanehara Foundation, Suzuken Memorial Foundation, The Nakatomi Foundation, Smoking Research Foundation, Takeda Science Foundation, The Mochida Memorial Foundation for Medical and Pharmaceutical Research, Sumitomo Denko Foundation, Mitsui Sumitomo Insurance Welfare Foundation to T.I., and Otsuka Toshimi Scholarship Foundation, Fujii-Otsuka Scholarship to I.H.
Funding Information:
This work was supported by the grants provided by JSPS KAKENHI (Grant Numbers. 25713063 , 15K15757 , 17K19758 , 18H03011 to T.I.), The Ichiro Kanehara Foundation , Suzuken Memorial Foundation , The Nakatomi Foundation , Smoking Research Foundation , Takeda Science Foundation , The Mochida Memorial Foundation for Medical and Pharmaceutical Research, Sumitomo Denko Foundation , Mitsui Sumitomo Insurance Welfare Foundation to T.I. , and Otsuka Toshimi Scholarship Foundation , Fujii-Otsuka Scholarship to I.H.
Publisher Copyright:
© 2018 The Authors
PY - 2019/11
Y1 - 2019/11
N2 - Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P1 signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis.
AB - Rheumatoid arthritis (RA) mainly affects various joints of the body, including the temporomandibular joint (TMJ), and it involves an infiltration of autoantibodies and inflammatory leukocytes into articular tissues and the synovium. Initially, the synovial lining tissue becomes engaged with several kinds of infiltrating cells, including osteoclasts, macrophages, lymphocytes, and plasma cells. Eventually, bone degradation occurs. In order to elucidate the best therapy for RA, a comprehensive study of RA pathogenesis needs to be completed. In this article, we discuss a Fas-deficient condition which develops into RA, with an emphasis on the role of sphingosine 1-phosphate (S1P)/S1P receptor 1 signaling which induces the migration of osteoclast precursor cells. We describe that Fas/S1P1 signaling via NF-κB activation in osteoclasts is a key factor in TMJ-RA severity and we discuss a strategy for blocking nuclear translocation of the p50 NF-κB subunit as a potential therapy for attenuating osteoclastogenesis.
KW - Fas
KW - NF-κB
KW - Osteoclast
KW - Rheumatoid arthritis
KW - S1P
KW - Temporomandibular joint
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U2 - 10.1016/j.jdsr.2018.09.004
DO - 10.1016/j.jdsr.2018.09.004
M3 - Review article
AN - SCOPUS:85055502190
SN - 1882-7616
VL - 55
SP - 12
EP - 19
JO - Dentistry in Japan
JF - Dentistry in Japan
IS - 1
ER -