Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse

Ikuo Yamamoto, Kazuhito Watanabe, Shizuo Narimatsu, Koichi Hamajima, Hidetoshi Yoshimura

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

When a 5 mg/kg i.v. dose of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ8-THC and 11-OH-Δ8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ8-THC was greater than that to Δ8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ8-THC has some role in the development of tolerance to the hypothermic effect of Δ8-THC in mice.

Original languageEnglish
Pages (from-to)159-166
Number of pages8
JournalEuropean Journal of Pharmacology
Volume111
Issue number2
DOIs
Publication statusPublished - 1985
Externally publishedYes

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Dronabinol
Chlorpromazine
Cannabinoids
Reserpine
Pentobarbital
Morphine
hydroxide ion

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse. / Yamamoto, Ikuo; Watanabe, Kazuhito; Narimatsu, Shizuo; Hamajima, Koichi; Yoshimura, Hidetoshi.

In: European Journal of Pharmacology, Vol. 111, No. 2, 1985, p. 159-166.

Research output: Contribution to journalArticle

Yamamoto, Ikuo ; Watanabe, Kazuhito ; Narimatsu, Shizuo ; Hamajima, Koichi ; Yoshimura, Hidetoshi. / Cross-tolerance to the hypothermic effect of Δ8-tetrahydrocannabinol 11-hydroxy-Δ8-tetrahydrocannabinol and chlorpromazine in the mouse. In: European Journal of Pharmacology. 1985 ; Vol. 111, No. 2. pp. 159-166.
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AU - Watanabe, Kazuhito

AU - Narimatsu, Shizuo

AU - Hamajima, Koichi

AU - Yoshimura, Hidetoshi

PY - 1985

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AB - When a 5 mg/kg i.v. dose of Δ8-tetrahydrocannabinol (Δ8-THC) and 11-hydroxy-Δ8-tetrahydrocannabinol (11-OH-Δ8-THC) was administered daily to mice, tolerance to their hypothermic effects developed quickly. Cross-tolerance to the hypothermic effect also developed between Δ8-THC and 11-OH-Δ8-THC. Tolerance development was dose-dependent and dose-effect experiments indicated that the magnitude of the tolerance developed to 11-OH-Δ8-THC was greater than that to Δ8-THC. Both cannabinoids were cross-tolerant to chlorpromazine in the hypothermic effect, but not to morphine, pentobarbital and reserpine under the conditions used. The present results suggest that 11-OH-Δ8-THC has some role in the development of tolerance to the hypothermic effect of Δ8-THC in mice.

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