Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice

K. Watanabe, S. Narimatsu, I. Yamamoto, H. Yoshimura

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Repeated administration (5 mg kg-1 day-1 i.v.) of Δ8- tetrahydrocannabinol and its active metabolite, 11-hydroxy-Δ8-tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone-induced sleep in mice. Reciprocal cross-tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8-tetrahydrocannabinol. The results suggest that 11-hydroxy-Δ8-tetrahydrocannabinol plays an important role both in the sleep-prolonging effect of Δ8-tetrahydrocannabinol and its tolerance development.

Original languageEnglish
Pages (from-to)945-947
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume39
Issue number11
Publication statusPublished - 1987
Externally publishedYes

Fingerprint

Dronabinol
Pentobarbital
Sleep
Cannabinoids

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice. / Watanabe, K.; Narimatsu, S.; Yamamoto, I.; Yoshimura, H.

In: Journal of Pharmacy and Pharmacology, Vol. 39, No. 11, 1987, p. 945-947.

Research output: Contribution to journalArticle

@article{5240855ec63640febd9cfcd6057d5c8a,
title = "Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice",
abstract = "Repeated administration (5 mg kg-1 day-1 i.v.) of Δ8- tetrahydrocannabinol and its active metabolite, 11-hydroxy-Δ8-tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone-induced sleep in mice. Reciprocal cross-tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8-tetrahydrocannabinol. The results suggest that 11-hydroxy-Δ8-tetrahydrocannabinol plays an important role both in the sleep-prolonging effect of Δ8-tetrahydrocannabinol and its tolerance development.",
author = "K. Watanabe and S. Narimatsu and I. Yamamoto and H. Yoshimura",
year = "1987",
language = "English",
volume = "39",
pages = "945--947",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "11",

}

TY - JOUR

T1 - Cross-tolerance development to the prolongation of pentobarbitone-induced sleep by Δ8-tetrahydrocannabinol and 11-hydroxy-Δ8-tetrahydrocannabinol in mice

AU - Watanabe, K.

AU - Narimatsu, S.

AU - Yamamoto, I.

AU - Yoshimura, H.

PY - 1987

Y1 - 1987

N2 - Repeated administration (5 mg kg-1 day-1 i.v.) of Δ8- tetrahydrocannabinol and its active metabolite, 11-hydroxy-Δ8-tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone-induced sleep in mice. Reciprocal cross-tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8-tetrahydrocannabinol. The results suggest that 11-hydroxy-Δ8-tetrahydrocannabinol plays an important role both in the sleep-prolonging effect of Δ8-tetrahydrocannabinol and its tolerance development.

AB - Repeated administration (5 mg kg-1 day-1 i.v.) of Δ8- tetrahydrocannabinol and its active metabolite, 11-hydroxy-Δ8-tetrahydrocannabinol caused tolerance to develop to their prolonging effect on pentobarbitone-induced sleep in mice. Reciprocal cross-tolerance also developed after seven daily doses of these cannabinoids. The magnitude of the tolerance developed by the metabolite was greater than that by Δ8-tetrahydrocannabinol. The results suggest that 11-hydroxy-Δ8-tetrahydrocannabinol plays an important role both in the sleep-prolonging effect of Δ8-tetrahydrocannabinol and its tolerance development.

UR - http://www.scopus.com/inward/record.url?scp=0023547266&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023547266&partnerID=8YFLogxK

M3 - Article

VL - 39

SP - 945

EP - 947

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 11

ER -