Cross-excitation in peripheral sensory ganglia associated with pain transmission

Katsuhiro Omoto, Kotaro Maruhama, Ryuji Terayama, Yumiko Yamamoto, Osamu Matsushita, Tomosada Sugimoto, Keiji Oguma, Yoshizo Matsuka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Despite the absence of synaptic contacts, cross-excitation of neurons in sensory ganglia during signal transmission is considered to be chemically mediated and appears increased in chronic pain states. In this study, we modulated neurotransmitter release in sensory neurons by direct application of type A botulinum neurotoxin (BoNT/A) to sensory ganglia in an animal model of neuropathic pain and evaluated the effect of this treatment on nocifensive. Unilateral sciatic nerve entrapment (SNE) reduced the ipsilateral hindpaw withdrawal threshold to mechanical stimulation and reduced hindpaw withdrawal latency to thermal stimulation. Direct application of BoNT/A to the ipsilateral L4 dorsal root ganglion (DRG) was localized in the cell bodies of the DRG and reversed the SNE-induced decreases in withdrawal thresholds within 2 days of BoNT/A administration. Results from this study suggest that neurotransmitter release within sensory ganglia is involved in the regulation of pain-related signal transmission.

Original languageEnglish
Pages (from-to)2906-2917
Number of pages12
JournalToxins
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 4 2015

Fingerprint

Sensory Ganglia
Nerve Compression Syndromes
Spinal Ganglia
Sciatic Nerve
Pain
Neurons
Neurotransmitter Agents
Neurotoxins
Neuralgia
Sensory Receptor Cells
Chronic Pain
Animals
Animal Models
Hot Temperature
Cells
incobotulinumtoxinA
Therapeutics

Keywords

  • Botulinum toxin
  • Dorsal root ganglion
  • Mechanical allodynia
  • Transmitter release

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Cross-excitation in peripheral sensory ganglia associated with pain transmission. / Omoto, Katsuhiro; Maruhama, Kotaro; Terayama, Ryuji; Yamamoto, Yumiko; Matsushita, Osamu; Sugimoto, Tomosada; Oguma, Keiji; Matsuka, Yoshizo.

In: Toxins, Vol. 7, No. 8, 04.08.2015, p. 2906-2917.

Research output: Contribution to journalArticle

Omoto, Katsuhiro ; Maruhama, Kotaro ; Terayama, Ryuji ; Yamamoto, Yumiko ; Matsushita, Osamu ; Sugimoto, Tomosada ; Oguma, Keiji ; Matsuka, Yoshizo. / Cross-excitation in peripheral sensory ganglia associated with pain transmission. In: Toxins. 2015 ; Vol. 7, No. 8. pp. 2906-2917.
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