Abstract
In an aprotic solvent, dimethylformamide, a coupling reaction between an α,β-unsaturated ketone and an aldehyde is achieved with chromium(II) chloride. An intermolecular aldol reaction and an intramolecular cyclization proceed sequentially to give cis-2-hydroxyalkyl-substituted cyclopropanol stereoselectively [Eq. (a)].
| Original language | English |
|---|---|
| Pages (from-to) | 2725-2727 |
| Number of pages | 3 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 39 |
| Issue number | 15 |
| DOIs | |
| Publication status | Published - Aug 4 2000 |
Keywords
- Aldehydes
- Aldol reactions
- Chromium
- Cross-coupling
- Ketones
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
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Cite this
Toratsu, C., Fujii, T., Suzuki, T., & Takai, K. (2000). Cross-coupling reactions between α,β-unsaturated ketones and aldehydes with CrCl2: Aldol condensation and cyclopropanol formation. Angewandte Chemie - International Edition, 39(15), 2725-2727. https://doi.org/10.1002/1521-3773(20000804)39:15<2725::AID-ANIE2725>3.0.CO;2-U