Cross-coupling reactions between α,β-unsaturated ketones and aldehydes with CrCl2: Aldol condensation and cyclopropanol formation

Chika Toratsu, Takafumi Fujii, Takuma Suzuki, Kazuhiko Takai

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)


In an aprotic solvent, dimethylformamide, a coupling reaction between an α,β-unsaturated ketone and an aldehyde is achieved with chromium(II) chloride. An intermolecular aldol reaction and an intramolecular cyclization proceed sequentially to give cis-2-hydroxyalkyl-substituted cyclopropanol stereoselectively [Eq. (a)].

Original languageEnglish
Pages (from-to)2725-2727
Number of pages3
JournalAngewandte Chemie - International Edition
Issue number15
Publication statusPublished - Aug 4 2000


  • Aldehydes
  • Aldol reactions
  • Chromium
  • Cross-coupling
  • Ketones

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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