Abstract
In an aprotic solvent, dimethylformamide, a coupling reaction between an α,β-unsaturated ketone and an aldehyde is achieved with chromium(II) chloride. An intermolecular aldol reaction and an intramolecular cyclization proceed sequentially to give cis-2-hydroxyalkyl-substituted cyclopropanol stereoselectively [Eq. (a)].
Original language | English |
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Pages (from-to) | 2725-2727 |
Number of pages | 3 |
Journal | Angewandte Chemie - International Edition |
Volume | 39 |
Issue number | 15 |
DOIs | |
Publication status | Published - Aug 4 2000 |
Keywords
- Aldehydes
- Aldol reactions
- Chromium
- Cross-coupling
- Ketones
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)