In an aprotic solvent, dimethylformamide, a coupling reaction between an α,β-unsaturated ketone and an aldehyde is achieved with chromium(II) chloride. An intermolecular aldol reaction and an intramolecular cyclization proceed sequentially to give cis-2-hydroxyalkyl-substituted cyclopropanol stereoselectively [Eq. (a)].
|Number of pages||3|
|Journal||Angewandte Chemie - International Edition|
|Publication status||Published - Aug 4 2000|
- Aldol reactions
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