Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate?

Atsunori Nakao, Hiromi Iwagaki, Taiichiro Kanagawa, Atsushi Jikuhara, Nagahide Matsubara, Norihisa Takakura, Hiroshi Isozaki, Noriaki Tanaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We report a 27-year-old female with Crohn's disease clinically misdiagnosed with intestinal endometriosis. Her complaints were abdominal pain and fullness, which occurred monthly during her menstual period. Although we had no histopathological evidence, we diagnosed her as bowel endometriosis on the basis of her clinical course. Since nafarelin acetate therapy started, the symptoms due to mechanical subileus have improved. The transverse colon, a 70 cm segment of the ileum, including the terminal ileum, were resected because of repeated symptoms of bowel obstruction despite prolonged nafarelin therapy. Histopathological findings of the resected specimen revealed Crohn's disease without endometrial tissue. In our patient, an increased cortisol and ACTH secretion, a side effect of nafarelin, was noted during the therapy. This case showed that nafarelin therapy could increase serum concentration of ACTH and cortisol, which was considered to suppress the pathology of Crohn's disease by its anti-inflammatory action. We emphasize that intestinal examination must be performed with Crohn's disease in mind, even if nafarelin acetate is effective.

Original languageEnglish
Pages (from-to)131-133
Number of pages3
JournalArchives of Gynecology and Obstetrics
Volume263
Issue number3
Publication statusPublished - Feb 2000

Fingerprint

Nafarelin
Endometriosis
Crohn Disease
Ileum
Adrenocorticotropic Hormone
Hydrocortisone
Transverse Colon
Therapeutics
Diagnostic Errors
Abdominal Pain
Anti-Inflammatory Agents
Pathology
Serum

Keywords

  • Bowel endometriosis
  • Crohn's disease
  • Nafarelin acetate

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Nakao, A., Iwagaki, H., Kanagawa, T., Jikuhara, A., Matsubara, N., Takakura, N., ... Tanaka, N. (2000). Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate? Archives of Gynecology and Obstetrics, 263(3), 131-133.

Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate? / Nakao, Atsunori; Iwagaki, Hiromi; Kanagawa, Taiichiro; Jikuhara, Atsushi; Matsubara, Nagahide; Takakura, Norihisa; Isozaki, Hiroshi; Tanaka, Noriaki.

In: Archives of Gynecology and Obstetrics, Vol. 263, No. 3, 02.2000, p. 131-133.

Research output: Contribution to journalArticle

Nakao, A, Iwagaki, H, Kanagawa, T, Jikuhara, A, Matsubara, N, Takakura, N, Isozaki, H & Tanaka, N 2000, 'Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate?', Archives of Gynecology and Obstetrics, vol. 263, no. 3, pp. 131-133.
Nakao A, Iwagaki H, Kanagawa T, Jikuhara A, Matsubara N, Takakura N et al. Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate? Archives of Gynecology and Obstetrics. 2000 Feb;263(3):131-133.
Nakao, Atsunori ; Iwagaki, Hiromi ; Kanagawa, Taiichiro ; Jikuhara, Atsushi ; Matsubara, Nagahide ; Takakura, Norihisa ; Isozaki, Hiroshi ; Tanaka, Noriaki. / Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate?. In: Archives of Gynecology and Obstetrics. 2000 ; Vol. 263, No. 3. pp. 131-133.
@article{b4ee41955a414effab95da94d570d412,
title = "Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate?",
abstract = "We report a 27-year-old female with Crohn's disease clinically misdiagnosed with intestinal endometriosis. Her complaints were abdominal pain and fullness, which occurred monthly during her menstual period. Although we had no histopathological evidence, we diagnosed her as bowel endometriosis on the basis of her clinical course. Since nafarelin acetate therapy started, the symptoms due to mechanical subileus have improved. The transverse colon, a 70 cm segment of the ileum, including the terminal ileum, were resected because of repeated symptoms of bowel obstruction despite prolonged nafarelin therapy. Histopathological findings of the resected specimen revealed Crohn's disease without endometrial tissue. In our patient, an increased cortisol and ACTH secretion, a side effect of nafarelin, was noted during the therapy. This case showed that nafarelin therapy could increase serum concentration of ACTH and cortisol, which was considered to suppress the pathology of Crohn's disease by its anti-inflammatory action. We emphasize that intestinal examination must be performed with Crohn's disease in mind, even if nafarelin acetate is effective.",
keywords = "Bowel endometriosis, Crohn's disease, Nafarelin acetate",
author = "Atsunori Nakao and Hiromi Iwagaki and Taiichiro Kanagawa and Atsushi Jikuhara and Nagahide Matsubara and Norihisa Takakura and Hiroshi Isozaki and Noriaki Tanaka",
year = "2000",
month = "2",
language = "English",
volume = "263",
pages = "131--133",
journal = "Archives of Gynecology and Obstetrics",
issn = "0932-0067",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Crohn's disease mimicking as bowel endometriosis. Are the symptoms reduced by nafarelin acetate?

AU - Nakao, Atsunori

AU - Iwagaki, Hiromi

AU - Kanagawa, Taiichiro

AU - Jikuhara, Atsushi

AU - Matsubara, Nagahide

AU - Takakura, Norihisa

AU - Isozaki, Hiroshi

AU - Tanaka, Noriaki

PY - 2000/2

Y1 - 2000/2

N2 - We report a 27-year-old female with Crohn's disease clinically misdiagnosed with intestinal endometriosis. Her complaints were abdominal pain and fullness, which occurred monthly during her menstual period. Although we had no histopathological evidence, we diagnosed her as bowel endometriosis on the basis of her clinical course. Since nafarelin acetate therapy started, the symptoms due to mechanical subileus have improved. The transverse colon, a 70 cm segment of the ileum, including the terminal ileum, were resected because of repeated symptoms of bowel obstruction despite prolonged nafarelin therapy. Histopathological findings of the resected specimen revealed Crohn's disease without endometrial tissue. In our patient, an increased cortisol and ACTH secretion, a side effect of nafarelin, was noted during the therapy. This case showed that nafarelin therapy could increase serum concentration of ACTH and cortisol, which was considered to suppress the pathology of Crohn's disease by its anti-inflammatory action. We emphasize that intestinal examination must be performed with Crohn's disease in mind, even if nafarelin acetate is effective.

AB - We report a 27-year-old female with Crohn's disease clinically misdiagnosed with intestinal endometriosis. Her complaints were abdominal pain and fullness, which occurred monthly during her menstual period. Although we had no histopathological evidence, we diagnosed her as bowel endometriosis on the basis of her clinical course. Since nafarelin acetate therapy started, the symptoms due to mechanical subileus have improved. The transverse colon, a 70 cm segment of the ileum, including the terminal ileum, were resected because of repeated symptoms of bowel obstruction despite prolonged nafarelin therapy. Histopathological findings of the resected specimen revealed Crohn's disease without endometrial tissue. In our patient, an increased cortisol and ACTH secretion, a side effect of nafarelin, was noted during the therapy. This case showed that nafarelin therapy could increase serum concentration of ACTH and cortisol, which was considered to suppress the pathology of Crohn's disease by its anti-inflammatory action. We emphasize that intestinal examination must be performed with Crohn's disease in mind, even if nafarelin acetate is effective.

KW - Bowel endometriosis

KW - Crohn's disease

KW - Nafarelin acetate

UR - http://www.scopus.com/inward/record.url?scp=0034015303&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034015303&partnerID=8YFLogxK

M3 - Article

C2 - 10763842

AN - SCOPUS:0034015303

VL - 263

SP - 131

EP - 133

JO - Archives of Gynecology and Obstetrics

JF - Archives of Gynecology and Obstetrics

SN - 0932-0067

IS - 3

ER -