Crohn's Disease Associated with Growth Hormone Secretory Dysfunction

Toshio Ogura, Yasuo Itano, Takayoshi Yamauchi, Tetsuya Oishi, Tetsushi Aita, Nobuhiko Hayakawa, Takashi Ogasa, Kosuke Ota, Zensuke Ota, Jingo Kageyama, Kozo Hashimoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A 10-year-old boy presented in 1989 with repeated episodes of vomiting, abdominal distension and severe growth retardation. Endocrinologic examination indicated growth hormone (GH) secretory dysfunction. Administration of recombinant human GH (rhGH) led to growth, but the patient discontinued treatment. He was readmitted to our hospital in 1993, at the age of 16. His stature was very short. Laboratory findings suggested malnutrition. Radiologic examination revealed regional stenosis and a cobblestone appearance of the intestine. The histologic diagnosis was compatible with Crohn's disease. Administration of prednisolone alleviated gastrointestinal symptoms with the improvement of GH secretory function.

Original languageEnglish
Pages (from-to)112-117
Number of pages6
JournalInternal Medicine
Volume34
Issue number2
DOIs
Publication statusPublished - Jan 1 1995

Keywords

  • glucocorticoid therapy
  • neurosecretory dysfunction
  • pituitary dwarfism
  • short stature

ASJC Scopus subject areas

  • Internal Medicine

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    Ogura, T., Itano, Y., Yamauchi, T., Oishi, T., Aita, T., Hayakawa, N., Ogasa, T., Ota, K., Ota, Z., Kageyama, J., & Hashimoto, K. (1995). Crohn's Disease Associated with Growth Hormone Secretory Dysfunction. Internal Medicine, 34(2), 112-117. https://doi.org/10.2169/internalmedicine.34.112