Critical appraisal of the 1977 diagnostic criteria for minamata disease

Takashi Yorifuji, Toshihide Tsuda, Sachiko Inoue, Soshi Takao, Masazumi Harada, Ichiro Kawachi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Large-scale food poisoning caused bymethylmercury was identified in Minamata, Japan, in the 1950s (Minamata disease). Although the diagnostic criteria for the disease remain current, few studies have been carried out to assess the diagnostic accuracy of the criteria. From a 1971 populationbased investigation, data from 2 villages were selected: Minamata (high-exposure area; n = 779) and Ariake (low-exposure area; n = 755). The authors examined the prevalence of neurologic signs characteristic of methylmercury poisoning and the validity of the criteria. A substantial number of residents in the exposed area exhibited neurologic signs even after excluding officially certified patients. Using paresthesia of the extremities as the gold standard of diagnosis, the criteria had a sensitivity of 66%. The current diagnostic criteria as well as the official certification system substantially underestimate the incidence of Minamata disease.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalArchives of Environmental and Occupational Health
Volume68
Issue number1
DOIs
Publication statusPublished - 2013

Keywords

  • Environmental pollution
  • Epidemiological studies
  • Methylmercury compounds
  • Minamata disease
  • Sensitivity and specificity

ASJC Scopus subject areas

  • Toxicology
  • Environmental Science(all)
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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