Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures: A case report and literature review

Keita Miyake, Takashi Hara, Etsuko Oshima, Kiyohiro Kawada, Hideki Ishizu, Yuko Yamauchi, Katsuya Satoh, Tetsuyuki Kitamoto, Shintaro Takenoshita, Seishi Terada, Norihito Yamada

Research output: Contribution to journalArticle

Abstract

Background: Creutzfeldt-Jakob disease (CJD) is a fatal neurodegenerative disease. Common first symptoms are dementia, cerebellar ataxia, visual disturbance, and psychiatric symptoms. Seizure as the first symptom of CJD is a very rare finding. Case presentation: We experienced an elderly woman who presented initially with status epilepticus following repeated partial seizures in the course of Alzheimer disease (AD) dementia. Anti-convulsive therapy had no effect. Autopsy revealed definite CJD with AD pathology. Coclusions: This is the first reported CJD case presenting with status epilepticus in the course of AD dementia.

Original languageEnglish
Article number54
JournalBMC Neurology
Volume18
Issue number1
DOIs
Publication statusPublished - Apr 25 2018

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Creutzfeldt-Jakob Syndrome
Status Epilepticus
Alzheimer Disease
Seizures
Pathology
Convulsive Therapy
Cerebellar Ataxia
Neurodegenerative Diseases
Psychiatry
Dementia
Autopsy

Keywords

  • Alzheimer disease
  • Creutzfeldt-Jakob disease
  • Epilepsy
  • Seizure
  • Status epilepticus

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures : A case report and literature review. / Miyake, Keita; Hara, Takashi; Oshima, Etsuko; Kawada, Kiyohiro; Ishizu, Hideki; Yamauchi, Yuko; Satoh, Katsuya; Kitamoto, Tetsuyuki; Takenoshita, Shintaro; Terada, Seishi; Yamada, Norihito.

In: BMC Neurology, Vol. 18, No. 1, 54, 25.04.2018.

Research output: Contribution to journalArticle

Miyake, Keita ; Hara, Takashi ; Oshima, Etsuko ; Kawada, Kiyohiro ; Ishizu, Hideki ; Yamauchi, Yuko ; Satoh, Katsuya ; Kitamoto, Tetsuyuki ; Takenoshita, Shintaro ; Terada, Seishi ; Yamada, Norihito. / Creutzfeldt-Jakob disease with Alzheimer pathology, presenting with status epilepticus following repeated partial seizures : A case report and literature review. In: BMC Neurology. 2018 ; Vol. 18, No. 1.
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