Seventeen patients with titers of RNP antibody over 1 : 10,000 seen at our clinic from 1981 to 1986 were investigated. (1) Five had systemic lupus erythematosus (SLE), 3 progressive systemic sclerosis (PSS), 7 mixed connective tissue disease (MCTD) and 2 unclassified connective tissue disease (UCTD). (2) Six of 7 with MCTD, both of 2 patients with UCTD and 1 of 3 with PSS had high titers of RNP antibody alone. (3) All 5 patients with SLE and 2 of 3 patients with PSS had both antiDNA antibody and antiSm antibody. (4) Raynaud's phenomenon was present in 12, but serious renal disease was not evident in any patient. The response to corticosteroid was positive in all patients.
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