Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients

Tetsuhito Fukushima, Xiaodong Tan, Yunwen Luo, Puqing Wang, Jinhui Song, Hideyuki Kanda, Takehito Hayakawa, Tomohiro Kumagai, Takeyasu Kakamu, Masayoshi Tsuji, Tomoo Hidaka, Yayoi Mori

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

OBJECTIVES: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects.

METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals.

RESULTS: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls.

CONCLUSIONS: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist.

Original languageEnglish
Pages (from-to)108-115
Number of pages8
JournalFukushima journal of medical science
Volume60
Issue number2
DOIs
Publication statusPublished - Jan 1 2014
Externally publishedYes

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Heavy Metals
Parkinson Disease
Urine
Depression
Manganese
Zinc
Metals
Hematologic Diseases
Ambulatory Care Facilities
China
Iron

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients. / Fukushima, Tetsuhito; Tan, Xiaodong; Luo, Yunwen; Wang, Puqing; Song, Jinhui; Kanda, Hideyuki; Hayakawa, Takehito; Kumagai, Tomohiro; Kakamu, Takeyasu; Tsuji, Masayoshi; Hidaka, Tomoo; Mori, Yayoi.

In: Fukushima journal of medical science, Vol. 60, No. 2, 01.01.2014, p. 108-115.

Research output: Contribution to journalArticle

Fukushima, T, Tan, X, Luo, Y, Wang, P, Song, J, Kanda, H, Hayakawa, T, Kumagai, T, Kakamu, T, Tsuji, M, Hidaka, T & Mori, Y 2014, 'Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients', Fukushima journal of medical science, vol. 60, no. 2, pp. 108-115. https://doi.org/10.5387/fms.2014-8
Fukushima, Tetsuhito ; Tan, Xiaodong ; Luo, Yunwen ; Wang, Puqing ; Song, Jinhui ; Kanda, Hideyuki ; Hayakawa, Takehito ; Kumagai, Tomohiro ; Kakamu, Takeyasu ; Tsuji, Masayoshi ; Hidaka, Tomoo ; Mori, Yayoi. / Correlations among heavy metals in blood and urine and their relations to depressive symptoms in Parkinson's disease patients. In: Fukushima journal of medical science. 2014 ; Vol. 60, No. 2. pp. 108-115.
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abstract = "OBJECTIVES: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that {"}two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe{"} was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals.RESULTS: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls.CONCLUSIONS: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist.",
author = "Tetsuhito Fukushima and Xiaodong Tan and Yunwen Luo and Puqing Wang and Jinhui Song and Hideyuki Kanda and Takehito Hayakawa and Tomohiro Kumagai and Takeyasu Kakamu and Masayoshi Tsuji and Tomoo Hidaka and Yayoi Mori",
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AU - Fukushima, Tetsuhito

AU - Tan, Xiaodong

AU - Luo, Yunwen

AU - Wang, Puqing

AU - Song, Jinhui

AU - Kanda, Hideyuki

AU - Hayakawa, Takehito

AU - Kumagai, Tomohiro

AU - Kakamu, Takeyasu

AU - Tsuji, Masayoshi

AU - Hidaka, Tomoo

AU - Mori, Yayoi

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N2 - OBJECTIVES: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals.RESULTS: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls.CONCLUSIONS: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist.

AB - OBJECTIVES: From our previous results, manganese (Mn) and iron (Fe) in the blood of Parkinson's disease (PD) patients without depression were higher than those of both the PD patients with depression and controls, the hypothesis that "two types of PD exist-PD without depression and affected by Mn and Fe, and PD with depression and unaffected by Mn or Fe" was induced. To investigate the hypothesis, correlations among blood and urine metals were compared in the subjects.METHODS: Subjects comprised PD patients with depression, PD patients without depression and controls recruited from an outpatient clinic in China. Morning blood and urine samples were used to measure concentrations of metals.RESULTS: In the controls, Mn, Fe and zinc (Zn) levels in blood strongly correlated with each other. The correlation coefficient between Mn and Zn in blood was significant in the PD patients with depression and the controls, but not in the PD patients without depression. Correlations of Fe between blood and urine in the PD patients without depression were significant, but not in the PD patients with depression and the controls.CONCLUSIONS: A common route of simultaneous intake of Mn, Fe and Zn could exist in our subjects, however in PD patients without depression, a large intake of Mn may have been from another route. Some results of the PD patients without depression were different from those of the PD patients with depression and the controls. Thus, two types of PD may exist.

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