Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient

Midori Isobe, Shingo Eikawa, Akiko Uenaka, Yoichi Nakamura, Tetsuo Kanda, Shigeru Kohno, Kiyotaka Kuzushima, Eiichi Nakayama

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

Original languageEnglish
Pages (from-to)8
Number of pages1
JournalCancer immunity : a journal of the Academy of Cancer Immunology
Volume9
Publication statusPublished - Jan 19 2009

Fingerprint

Regulatory T-Lymphocytes
Immunity
Lung Neoplasms
Immunoglobulin G
T-Lymphocytes
Recurrence
Antibodies
Neoplasms
Neoplasm Metastasis
Adenocarcinoma of lung

Keywords

  • Cellular immunity
  • Human
  • Humoral immunity
  • Lung cancer
  • NY-ESO-1

ASJC Scopus subject areas

  • Cancer Research
  • Immunology

Cite this

Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient. / Isobe, Midori; Eikawa, Shingo; Uenaka, Akiko; Nakamura, Yoichi; Kanda, Tetsuo; Kohno, Shigeru; Kuzushima, Kiyotaka; Nakayama, Eiichi.

In: Cancer immunity : a journal of the Academy of Cancer Immunology, Vol. 9, 19.01.2009, p. 8.

Research output: Contribution to journalArticle

Isobe, Midori ; Eikawa, Shingo ; Uenaka, Akiko ; Nakamura, Yoichi ; Kanda, Tetsuo ; Kohno, Shigeru ; Kuzushima, Kiyotaka ; Nakayama, Eiichi. / Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient. In: Cancer immunity : a journal of the Academy of Cancer Immunology. 2009 ; Vol. 9. pp. 8.
@article{cd56715a96624f6aa1d67e69378a6029,
title = "Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient",
abstract = "We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.",
keywords = "Cellular immunity, Human, Humoral immunity, Lung cancer, NY-ESO-1",
author = "Midori Isobe and Shingo Eikawa and Akiko Uenaka and Yoichi Nakamura and Tetsuo Kanda and Shigeru Kohno and Kiyotaka Kuzushima and Eiichi Nakayama",
year = "2009",
month = "1",
day = "19",
language = "English",
volume = "9",
pages = "8",
journal = "Cancer immunology research",
issn = "2326-6066",
publisher = "American Association for Cancer Research Inc.",

}

TY - JOUR

T1 - Correlation of high and decreased NY-ESO-1 immunity to spontaneous regression and subsequent recurrence in a lung cancer patient

AU - Isobe, Midori

AU - Eikawa, Shingo

AU - Uenaka, Akiko

AU - Nakamura, Yoichi

AU - Kanda, Tetsuo

AU - Kohno, Shigeru

AU - Kuzushima, Kiyotaka

AU - Nakayama, Eiichi

PY - 2009/1/19

Y1 - 2009/1/19

N2 - We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

AB - We show correlation between strong and decreased NY-ESO-1-specific immunity with spontaneous regression and subsequent recurrence, respectively, in a long-surviving patient with an NY-ESO-1-expressing lung adenocarcinoma. An integrated immune response consisting of IgG antibody, as well as CD4 and CD8 T cells, against NY-ESO-1 was observed at the time of spontaneous regression of multiple pleural metastases. After tumor dormancy for 3 years, the tumor started to progress. IgG antibody levels and the number of CD4 and CD8 T cells against NY-ESO-1 decreased, but were still detectable. On the other hand, the number of Foxp3+ CD25 high T regulatory cells gradually increased. The findings suggest the relevance of the NY-ESO-1 immune response and its regulation by Foxp3+ CD25 high T regulatory cells in the clinical course of this lung cancer patient.

KW - Cellular immunity

KW - Human

KW - Humoral immunity

KW - Lung cancer

KW - NY-ESO-1

UR - http://www.scopus.com/inward/record.url?scp=73449144847&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=73449144847&partnerID=8YFLogxK

M3 - Article

C2 - 19791734

AN - SCOPUS:74749106888

VL - 9

SP - 8

JO - Cancer immunology research

JF - Cancer immunology research

SN - 2326-6066

ER -