TY - JOUR
T1 - Correlation of computed tomography imaging features and pathological features of 41 patients with pancreatic neuroendocrine tumors
AU - Utsumi, Masashi
AU - Umeda, Yuzo
AU - Takagi, Kosei
AU - Kuise, Takashi
AU - Nobuoka, Daisuke
AU - Yoshida, Ryuichi
AU - Shinoura, Susumu
AU - Sadamori, Hiroshi
AU - Yagi, Takahito
AU - Fujiwara, Toshiyoshi
N1 - Publisher Copyright:
© H.G.E. Update Medical Publishing S.A., Athens-Stuttgart.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Background:/Aims: Pancreatic neuroendocrine tumors (PNET) are relatively rare. Here, we present clinical and pathological characteristics of PNETs to show a relationship between computed tomography (CT) imaging and the 2010 World Health Organization (WHO) classification. Methodology: We retrospectively reviewed the records of 41 PNET patients who were treated between 2002 and 2012. All tumors were classified as neuroendocrine tumor (NET) grade 1 (G1), NET grade 2 (G2), or neuroendocrine carcinoma (NEC) grade 3 (G3) on the basis of the 2010 WHO classification system. Results: Twenty-five tumors were classified as Gl, 11 as G2, and five as G3. Mean sizes of the Gl, G2 and G3 tumors were 1.84 + 0.54, 4.90 ± 0.84, and 5.62 ± 1.18 cm, respectively, (P < 0.01). A PNET is typically hypervascular and exhibits contrast enhancement on enhanced CT. Higher percentage of Gl tumors demonstrated typical imaging and showed a significantly greater distinct mass compared with G2 and G3 tumors. Conclusions: Although PNET has many imaging features that appear on CT, G2 and G3 tumors often show atypical imaging features, particularly with large sizes and/or ill-defined features, when compared with Gl tumors. If a PNET has atypical imaging features, possibility of malignancy should be considered.
AB - Background:/Aims: Pancreatic neuroendocrine tumors (PNET) are relatively rare. Here, we present clinical and pathological characteristics of PNETs to show a relationship between computed tomography (CT) imaging and the 2010 World Health Organization (WHO) classification. Methodology: We retrospectively reviewed the records of 41 PNET patients who were treated between 2002 and 2012. All tumors were classified as neuroendocrine tumor (NET) grade 1 (G1), NET grade 2 (G2), or neuroendocrine carcinoma (NEC) grade 3 (G3) on the basis of the 2010 WHO classification system. Results: Twenty-five tumors were classified as Gl, 11 as G2, and five as G3. Mean sizes of the Gl, G2 and G3 tumors were 1.84 + 0.54, 4.90 ± 0.84, and 5.62 ± 1.18 cm, respectively, (P < 0.01). A PNET is typically hypervascular and exhibits contrast enhancement on enhanced CT. Higher percentage of Gl tumors demonstrated typical imaging and showed a significantly greater distinct mass compared with G2 and G3 tumors. Conclusions: Although PNET has many imaging features that appear on CT, G2 and G3 tumors often show atypical imaging features, particularly with large sizes and/or ill-defined features, when compared with Gl tumors. If a PNET has atypical imaging features, possibility of malignancy should be considered.
KW - Computed tomography
KW - Neuroendocrine tumor
KW - Pancreas
KW - WHO
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U2 - 10.5754/hge14388
DO - 10.5754/hge14388
M3 - Article
C2 - 25916078
AN - SCOPUS:84928579955
VL - 62
SP - 441
EP - 446
JO - Hepato-Gastroenterology
JF - Hepato-Gastroenterology
SN - 0172-6390
IS - 138
ER -