Correlation of cerebral spinal fluid pH and HCO 3 - with disease progression in ALS

Nobutoshi Morimoto, Kentaro Deguchi, Kota Sato, Taijun Yunoki, Shoko Deguchi, Yasuyuki Ohta, Tomoko Kurata, Yoshiki Takao, Yoshio Ikeda, Tohru Matsuura, Koji Abe

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Amyotrophic lateral sclerosis (ALS) is a progressive and fatal disease, which is characterized by progressive degeneration of spinal and bulbar innervating motor neurons. However, the underlying mechanisms of motor neuron death remain poorly understood. Several candidate disease biomarkers have been detected in cerebrospinal fluid of ALS patients. The present study analyzed various cerebral spinal fluid gas parameters in ALS patients and compared these values to controls, as well as patients with cervical spondylosis, Parkinson syndrome, and spinocerebellar degeneration. Cerebral spinal fluid pH positively correlated with the ALS functional rating scale in total and limb-type ALS patients. In addition, cerebral spinal fluid pH positively correlated with shorter disease duration (less than 22 weeks). These results suggested that cerebral spinal fluid pH provides a biomarker for ALS and could reflect mechanisms of disease progression in ALS patients.

Original languageEnglish
Pages (from-to)74-78
Number of pages5
JournalJournal of the neurological sciences
Volume307
Issue number1-2
DOIs
Publication statusPublished - Aug 15 2011

Keywords

  • Amyotrophic lateral sclerosis
  • Cerebrospinal fluid
  • Functional rating scale
  • pH

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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    Morimoto, N., Deguchi, K., Sato, K., Yunoki, T., Deguchi, S., Ohta, Y., Kurata, T., Takao, Y., Ikeda, Y., Matsuura, T., & Abe, K. (2011). Correlation of cerebral spinal fluid pH and HCO 3 - with disease progression in ALS. Journal of the neurological sciences, 307(1-2), 74-78. https://doi.org/10.1016/j.jns.2011.05.013